CORE--ANIMAL MODELS

核心--动物模型

• 批准号: 8116419
• 负责人: DAZHONG XU
• 金额: $ 36.2万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8116419
• 关键词: Animal Model; Animal Testing; Animals; Equipment; Goals; Grant; Hemorrhagic Shock; Location; Modeling; Physiological; Plasma; Registries; Reproducibility; Sampling; Shock; Source; Tissues; Trauma; cost

Animal modeling and the reproducibility of the model are important aspects in obtaining potentially clinically as well as biologically relevant information. Thus, the first goal of the Animal Models Core is to provide a well-controlled and consistent source of tissue, blood and plasma samples from animals subjected to the various models proposed in this grant to the Project leaders. The second goal is to promote the integration of the results obtained in the various projects with each other as well as to reduce costs and limit the number of animals required to carry out the proposed studies. By centralizing the expertise and equipment required to carry out the various trauma-hemorrhagic shock (T/HS) and trauma-sham-shock (T/SS) models in one location, the consistency of the results obtained will be increased, while the overall costs and number of animals used will be significantly reduced. Also by creating an animal registry, the results observed in specific animal tested in the different projects can be integrated with each other to form a more complete physiologic picture.

动物建模和模型的可重复性是在临床上获得潜在的重要方面 以及与生物学相关的信息。因此，动物模型核心的第一个目标是提供 受到动物的组织，血液和血浆样品的控制良好，一致的来源 向项目负责人提出的各种模型。第二个目标是促进 在各个项目中获得的结果的整合以及降低成本并限制 进行拟议的研究所需的动物数量。通过集中专业知识和 进行各种创伤性避免冲击（T/HS）和创伤震动所需的设备 （T/SS）模型在一个位置，获得的结果的一致性将增加，而总体 所用动物的成本和数量将大大减少。也通过创建动物注册中心 在不同项目中测试的特定动物中观察到的结果可以彼此集成以形成 更完整的生理图片。