Calcineurin Inhibition to Halt Aspergillus fumigatus Hyphae and Virulence

抑制钙调磷酸酶以阻止烟曲霉菌丝和毒力

• 批准号: 8145120
• 负责人: WILLIAM J STEINBACH
• 金额: $ 39.25万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145120
• 关键词: Advisory Committees; Affinity Chromatography; Americas; Animal Model; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Binding; Biochemical; Breathing; Calcineurin; Calcineurin Pathway; Cause of Death; Cell Wall; Cell physiology; Collection; Communicable Diseases; Data; Development; Diagnosis; Diagnostic; Disease; Eukaryotic Cell; Event; Genetic; Genetic Epistasis; Goals; Growth; Homeostasis; Human; Hyphae; Immune system; Immunocompromised Host; Incidence; Infection; Invaded; Knowledge; Laboratories; Lead; Link; Molecular; Molecular Models; Molecular Target; Mutagenesis; Mutation; Mycoses; Outcome; Pathogenesis; Pathogenicity; Patients; Phenotype; Phosphoric Monoester Hydrolases; Play; Process; Protein Dephosphorylation; Proteins; Public Health; Regulation; Reproduction spores; Research; Resources; Role; Signal Transduction; Societies; Testing; The science of Mycology; Therapeutic Intervention; Universities; Virulence; Work; base; design; experience; fungus; improved; molecular modeling; mortality; mutant; novel; novel diagnostics; novel therapeutics; pathogen; public health relevance; success; tool

项目成果

Newer combination antifungal therapies for invasive aspergillosis.

• DOI: 10.3109/13693786.2010.499374
• 发表时间: 2011-04
• 期刊: Medical mycology
• 影响因子: 2.9
• 作者: Steinbach WJ;Juvvadi PR;Fortwendel JR;Rogg LE
• 通讯作者: Rogg LE