The mechanisms of regulatory T-cell expansion in human Mycobacterium tuberculosis

人结核分枝杆菌调节性 T 细胞扩增的机制

• 批准号: 8145096
• 负责人: Ramakrishna Vankayalapati
• 金额: $ 35.25万
• 依托单位: UNIVERSITY OF TEXAS HLTH CTR AT TYLER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-23 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8145096
• 关键词: Activated Natural Killer Cell; Affect; Animal Model; Antitubercular Agents; Apoptotic; Autoimmunity; Bacteria; Binding; Biological Assay; Blood Cells; CD4 Positive T Lymphocytes; Cells; Cessation of life; Cytokine Inducible SH2-Containing Protein; Cytolysis; Data; Development; Disease; Genes; Growth; Heme; Human; IL2RA gene; Immune response; Immune system; Immunity; Infection; Lead; Mannose; Mediating; Methods; Molecular; Monokines; Mus; Mycobacterium tuberculosis; Natural Killer Cells; Nitric Oxide; Organ Transplantation; Oxygenases; Persons; Physiology; Play; Population; Production; Protozoa; Publishing; Regulatory T-Lymphocyte; Regulon; Resistance to infection; Role; Signal Pathway; Signal Transduction; Signaling Molecule; T cell response; T-Lymphocyte; Tissues; Tuberculin; Tuberculosis; Up-Regulation; Vaccines; Virus; Work; chromatin immunoprecipitation; design; heme oxygenase-1; improved; in vivo; insight; lipoarabinomannan; macrophage; mycobacterial; novel; pathogen; prevent; promoter; protein expression; public health relevance; receptor; response; tool; transcription factor; tumor

项目成果

Phosphorylated STAT3 and PD-1 regulate IL-17 production and IL-23 receptor expression in Mycobacterium tuberculosis infection.

• DOI: 10.1002/eji.201343680
• 发表时间: 2014-07
• 期刊: EUROPEAN JOURNAL OF IMMUNOLOGY
• 影响因子: 5.4
• 作者: Bandaru, Anuradha;Devalraju, Kamakshi P.;Paidipally, Padmaja;Dhiman, Rohan;Venkatasubramanian, Sambasivan;Barnes, Peter F.;Vankayalapati, Ramakrishna;Valluri, Vijayalakshmi
• 通讯作者: Valluri, Vijayalakshmi