Resolution and Regeneration in Periodontitis via Recruitment of Regulatory Lympho

通过招募调节性淋巴细胞来解决牙周炎并使其再生

• 批准号: 8112200
• 负责人: STEVEN R LITTLE
• 金额: $ 29.42万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8112200
• 关键词: Acute; Address; Affect; American; Anti-Inflammatory Agents; Anti-inflammatory; Arthritis; Attenuated; Autoimmune Diseases; Autoimmune Process; BMP2 gene; BMP4; BMP7 gene; Biological; Biological Assay; Bone Regeneration; Bone Resorption; CCL22 gene; Cardiovascular Diseases; Cells; Chemotactic Factors; Chemotaxis; Clinical; Control Groups; Data; Degenerative polyarthritis; Detection; Diabetes Mellitus; Disease; Disease Progression; Drug Delivery Systems; Drug Formulations; Effectiveness; Engineering; Environment; Enzyme-Linked Immunosorbent Assay; Equilibrium; Etiology; FDA approved; Functional disorder; Future; Gingiva; Glycolates; Homeostasis; Immune; Immune response; Immune system; Immunology; In Situ; In Vitro; Incidence; Infection; Inflammation; Inflammatory; Inflammatory Response; Interferon Type II; Interleukin-10; Interleukin-17; Interleukin-4; Kidney Diseases; Knockout Mice; Laboratories; Lead; Lesion; Leukocytes; Ligaments; Literature; Lung diseases; Lymphocyte; Lymphocyte Subset; Matrix Metalloproteinases; Mediating; Modeling; Molecular Biology; Monitor; Mus; Natural regeneration; Nature; Oral health; Osteocalcin; Osteoclasts; Osteogenesis; Patients; Pattern; Periodontal Diseases; Periodontitis; Periodontium; Pharmaceutical Preparations; Physiological; Play; Polymers; Population; Positioning Attribute; Premature Birth; Prevalence; Process; Proteins; Public Health; Publishing; Reaction; Recruitment Activity; Regulatory T-Lymphocyte; Research; Research Personnel; Resolution; Role; Severities; Side; Specificity; Symptoms; System; Systemic infection; TNFSF11 gene; Temporomandibular Joint; Testing; Therapeutic; Time; Tissue-Specific Gene Expression; Tissues; Tooth Loss; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Universities; Vasoactive Intestinal Peptide; Work; Wound Healing; arm; base; bone; cell motility; chemokine; chemokine receptor; controlled release; craniofacial; cytokine; design; follow-up; human TNF protein; in vivo; inflammatory marker; killings; mouse model; neutrophil; osteogenic; pathogen; periapical; periodontopathogen; premature; protein expression; public health relevance; residence; response; tissue regeneration

项目成果

Characterization of the Protective Role of Regulatory T Cells in Experimental Periapical Lesion Development and Their Chemoattraction Manipulation as a Therapeutic Tool.

• DOI: 10.1016/j.joen.2015.09.022
• 发表时间: 2016-01
• 期刊: Journal of endodontics
• 影响因子: 4.2
• 作者: Francisconi CF;Vieira AE;Biguetti CC;Glowacki AJ;Trombone AP;Letra A;Menezes Silva R;Sfeir CS;Little SR;Garlet GP
• 通讯作者: Garlet GP