Fas pathway in organ-specific tolerance and autoimmunity

Fas 通路在器官特异性耐受和自身免疫中的作用

• 批准号: 8124074
• 负责人: Abdel Rahim Hamad
• 金额: $ 41万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8124074
• 关键词: Ablation; Acute; Affect; Age; Allogenic; Animal Model; Antibodies; Antigens; Apoptotic; Autoimmune Diabetes; Autoimmune Diseases; Autoimmune Process; Autoimmunity; B-Lymphocyte Subsets; B-Lymphocytes; Beta Cell; Biological Assay; Bone Marrow; CD8B1 gene; Caspase; Cell Death; Cells; Cessation of life; Child; Chimera organism; Chronic; Data; Dendritic Cells; Development; Diabetes Mellitus; Disease; Frequencies; Genes; Genetic; Goals; Heterozygote; Homeostasis; Host Defense; Hyperglycemia; Immune response; Immunosuppression; Immunotherapy; Inbred NOD Mice; Infiltration; Insulin; Insulin-Dependent Diabetes Mellitus; Interleukin-10; Investigation; Islets of Langerhans Transplantation; Knock-out; Ligands; Mediating; Multiple Sclerosis; Mus; Mutation; Myeloid Cells; Nuclear; Organ; Pancreas; Pathogenesis; Pathway interactions; Physical condensation; Play; Population; Prevention; Process; Publishing; Recruitment Activity; Resistance; Role; Signal Transduction; Silicosis; Source; Staging; Surface; Syndrome; System; T-Lymphocyte; TNFRSF5 gene; Testing; Therapeutic; Time; Transplantation; Tumor Necrosis Factor Ligand Superfamily Member 6; cell type; chemokine; chronic autoimmune disease; cytokine; design; insight; interest; islet; lymph nodes; neutralizing monoclonal antibodies; novel; novel therapeutics; prevent; protective effect; public health relevance; research study; therapeutic target