Mechanisms and Functions of Core-induced Lipid Droplet Accumulation in Hepatitis

核心引起的肝炎脂滴积聚的机制和功能

• 批准号: 8132633
• 负责人: Melanie Maria Ott
• 金额: $ 48.25万
• 依托单位: J. DAVID GLADSTONE INSTITUTES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132633
• 关键词: 1,2-diacylglycerol; Acylation; Address; Affect; Alleles; Amino Acids; Anabolism; Antiviral Agents; Apoptosis; Architecture; Binding; Biogenesis; Capsid Proteins; Cell Line; Cell physiology; Cells; Chimeric Proteins; Cholesterol Esters; Clinical Management; Clinical Trials; Commit; Core Protein; Cytoplasmic Organelle; Data; Development; Diglycerides; Disease; Embryo; Endoplasmic Reticulum; Enzymes; Fatty Acids; Fatty Liver; Fibroblasts; Fractionation; Funding; Genotype; Goals; Grant; Hepatic; Hepatitis; Hepatitis B Virus; Hepatitis C; Hepatitis C virus; Hepatocyte; Homeostasis; Individual; Infection; Infectious hepatitides; Integration Host Factors; Laboratories; Life Cycle Stages; Link; Lipid Binding; Lipids; Lipolysis; Liver; Mediating; Membrane; Mitochondria; Modeling; Molecular; Monitor; Mus; Mutagenesis; Mutation; Nonstructural Protein; Nucleocapsid; Obesity associated disease; Open Reading Frames; Outer Mitochondrial Membrane; Pathogenesis; Patients; Pharmacologic Substance; Phospholipids; Physiological; Population; Primary carcinoma of the liver cells; Process; Production; Property; Protein Binding; Proteins; RNA; RNA Interference; RNA replication; Recruitment Activity; Regulation; Reporter; Resistance; Role; Side; Signal Transduction; Sister; Surface; Symptoms; Syndrome; Testing; Transgenic Mice; Triglycerides; United States National Institutes of Health; Ursidae Family; Viral; Viral Core Proteins; Viral Nonstructural Proteins; Viral Proteins; Virion; Virus; Virus Assembly; Virus Replication; cofactor; diacylglycerol O-acyltransferase; drug candidate; fatty acid oxidation; global health; hepatoma cell; in vivo; inhibitor/antagonist; insight; interest; knock-down; lipid metabolism; long chain fatty acid; monolayer; new therapeutic target; novel; particle; prevent; promoter; public health relevance; small hairpin RNA; tool; uptake; viral RNA; virus pathogenesis

项目成果

Unique ties between hepatitis C virus replication and intracellular lipids.

• DOI: 10.1016/j.tem.2011.03.004
• 发表时间: 2011-06
• 期刊: TRENDS IN ENDOCRINOLOGY AND METABOLISM
• 影响因子: 10.9
• 作者: Herker, Eva;Ott, Melanie
• 通讯作者: Ott, Melanie