CryoEM analysis of Anthrax Toxin Pore Complexes

炭疽毒素孔隙复合物的冷冻电镜分析

• 批准号: 8132761
• 负责人: Mark T Fisher
• 金额: $ 30万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132761
• 关键词: Address; Anthrax disease; Antigens; Arizona; Bacillus anthracis; Bacillus anthracis spore; Bacteremia; Bacterial Toxins; Binding; Biological Assay; Biotechnology; Bioterrorism; Breathing; Cessation of life; Chemicals; Clostridium; Collaborations; Complex; Computer Simulation; Coupled; Cryoelectron Microscopy; Cytoplasm; Data Set; Disease; Elements; Endosomes; Environment; Exotoxins; Foundations; Glean; Goals; Image; Infection; Kinetics; Knowledge; Length; Lipids; Livestock; Macromolecular Complexes; Medical; Membrane; Membrane Proteins; Methods; Modeling; Molecular; N-terminal; Nature; Negative Staining; Organism; Population; Pore Proteins; Procedures; Production; Property; Protein translocation; Proteins; Reproduction spores; Research; Research Personnel; Resolution; Screening procedure; Septic Toxemia; Structure; Surface; System; Techniques; Testing; Toxin; Universities; Work; anthrax lethal factor; anthrax toxin; antigen binding; base; comparative; edema factor; flexibility; improved; inhibitor/antagonist; molecular dynamics; mutant; novel; novel therapeutics; novel vaccines; particle; prophylactic; protein structure; public health relevance; reconstruction; scaffold; single molecule; small molecule; success; tool