The role of gammaherpesvirus protein kinase in lytic and latent infection

伽马疱疹病毒蛋白激酶在溶解性和潜伏性感染中的作用

• 批准号: 8132757
• 负责人: Vera L. Tarakanova
• 金额: $ 37.83万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8132757
• 关键词: Acute; Affect; Animal Model; Antiviral Agents; Biological; Biology; Cells; Chromatin; Chronic; DNA; DNA Damage; DNA Modification Process; DNA Packaging; Data; Developed Countries; Development; Embryo; Experimental Models; Family; Fibroblasts; Gene Expression; Genetic; Genetic Transcription; Goals; Herpesviridae; Histones; Human; Human Herpesvirus 4; Human Herpesvirus 8; Immune system; Immunocompromised Host; In Vitro; Infection; Investigation; Kinetics; Lead; Life Cycle Stages; Lymphomagenesis; Lytic; Lytic Phase; Malignant Neoplasms; Malignant lymphoid neoplasm; Mediating; Modeling; Mus; Pathogenesis; Peritoneal; Phosphotransferases; Prevention; Process; Protein Kinase; Regulation; Research; Risk Factors; Role; Route; Seroprevalences; Signal Pathway; Solid; Species Specificity; Structure; System; Testing; Transcript; Transcriptional Regulation; Viral; Viral Cancer; Viral Genes; Viral Proteins; Virus; Virus Diseases; Virus Latency; Virus Replication; base; cancer prevention; cell type; gammaherpesvirus; in vivo; insight; latent infection; lytic replication; macrophage; mouse model; novel; pathogen; public health relevance; research study; response; tool; tumorigenesis; virus host interaction

项目成果

Mouse gammaherpesvirus-68 infection acts as a rheostat to set the level of type I interferon signaling in primary macrophages.

小鼠 gammaherpesvirus-68 感染充当变阻器来设定原代巨噬细胞中 I 型干扰素信号传导的水平。

• DOI: 10.1016/j.virol.2013.04.036
• 发表时间: 2013
• 期刊: Virology
• 影响因子: 3.7
• 作者: Wood,BrittaniM;Mboko,WadzanaiP;Mounce,BryanC;Tarakanova,VeraL
• 通讯作者: Tarakanova,VeraL