Regulation of innate immune cell signaling by Skap-hom

Skap-hom 对先天免疫细胞信号传导的调节

• 批准号: 8122948
• 负责人: Kenneth Dean Swanson
• 金额: $ 39.14万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122948
• 关键词: 1-Phosphatidylinositol 4-Kinase; Actins; Acute; Adaptor Signaling Protein; Adhesions; Affect; Apolipoprotein E; Apoptosis; Atherosclerosis; Binding; Binding Proteins; Biochemical; Cellular biology; Chemotaxis; Chronic; Colitis; Complex; Cytoplasmic Tail; DNA Sequence Rearrangement; Data; Defect; Disease; Disease model; Event; Exhibits; Failure; Goals; Grant; Immigration; Immune; Immune system; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Integrins; Lead; Link; Mass Spectrum Analysis; Mediating; Mediator of activation protein; Molecular; Mus; Myelogenous; Myeloid Cells; PTPNS1 gene; Pathology; Phagocytes; Phenotype; Phosphatidylinositols; Phosphorylation; Phosphotransferases; Play; Process; Protein Binding; Proteins; Publishing; Receptor Signaling; Regulation; Respiratory Burst; Role; SHPS-1 protein; Severities; Signal Pathway; Signal Transduction; Sodium Dextran Sulfate; Stimulus; Structure; Testing; Therapeutic; Variant; adapter protein; base; cytokine; domain mapping; immune function; in vivo; insight; macrophage; migration; mouse model; neutrophil; novel; novel therapeutics; protein profiling; protein protein interaction; public health relevance; receptor; response; src-Family Kinases

项目成果

Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit.

• DOI: 10.1371/journal.pone.0125269
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Gera N;Yang A;Holtzman TS;Lee SX;Wong ET;Swanson KD
• 通讯作者: Swanson KD

Melanoma brain metastasis globally reconfigures chemokine and cytokine profiles in patient cerebrospinal fluid.

• DOI: 10.1097/cmr.0000000000000045
• 发表时间: 2014-04
• 期刊: Melanoma research
• 影响因子: 2.2
• 作者: Lok E;Chung AS;Swanson KD;Wong ET
• 通讯作者: Wong ET