通过 HIF 增强先天免疫来治疗耐药细菌感染-猫眼课题宝

通过 HIF 增强先天免疫来治疗耐药细菌感染

批准号：

8116223

负责人：

RANDALL Scott JOHNSON

金额：

$70.39万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

依托单位国家：

美国

项目类别：

财政年份：

2010

资助国家：

美国

项目状态：

已结题

起止时间：

2010-08-02 至 2011-07-31

来源：

https://reporter.nih.gov/project-details/8116223

关键词：

Abscess Address Agonist Alleles Anemia Anti-Bacterial Agents Anti-Infective Agents Antibiotic Resistance Antibiotic Therapy Antibiotics Apoptosis Apoptotic Ascaridil Bacteria Bacterial Infections Biological Products Biology Blood Cell Death Cells Cellular biology Chromatin Chronic Clinical Trials Collaborations Communicable Diseases Companions Cutaneous Cytoplasmic Granules Data Development Development Plans Discipline Disease Drug Delivery Systems Drug Design Drug Kinetics Drug resistance Elements Epithelial Epithelium Family Food Gene Expression Regulation Gene Targeting Generations Genes Genetic Goals Gold Healed Homeostasis Host Defense Human Hypoxia Immune Immune response Immunogenetics Immunology In Vitro Industry Infection Infectious Skin Diseases Inflammatory Investigational New Drug Application Iron Joints Journals Knockout Mice Knowledge Laboratories Laboratory Study Lead Leukocytes Lipopolysaccharides Lung Mammalian Genetics Manuscripts Mediating Medicine Metabolism Microbiology Modeling Molecular Molecular Immunology Mus Myelogenous Myeloid Cells NIH Program Announcements Natural Immunity Nature Necrosis Nitric Oxide Pathway interactions Pattern Peptide Hydrolases Phagocytes Pharmaceutical Preparations Pharmacologic Substance Pharmacology Physicians Physiology Pneumonia Positioning Attribute Preclinical Testing Procollagen-Proline Dioxygenase Production Pseudomonas Infections Pseudomonas aeruginosa Publications Publishing Puncture procedure Research Research Personnel Resistance Resolution Role Safety Skin Staphylococcal Infections Staphylococcus aureus System Systemic Therapy Therapeutic Tissues Toll-like receptors Topical agent Toxic effect Toxin Transcriptional Regulation Translational Research Vancomycin Virulence Work Wound Infection antimicrobial antimicrobial peptide bacterial resistance bactericide cytokine drug resistant bacteria extracellular healing hypoxia inducible factor 1 in vivo in vivo Model inhibitor/antagonist innate immune function innovation keratinocyte killings macrophage mast cell methicillin resistant Staphylococcus aureus microbial microbicide mouse model neutrophil novel novel therapeutic intervention novel therapeutics overexpression pathogen pre-clinical promoter response small molecule subcutaneous superinfection synergism tool transcription factor treatment strategy treatment trial wound

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批准号：

8210931
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$22.29万
财政年份：

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批准号：

8597539
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批准号：

8448237
项目类别：
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依托单位：

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批准号：

7356036
项目类别：
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财政年份：

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依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

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批准号：

7056216
项目类别：
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负责人：

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依托单位：

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批准号：

7173374
项目类别：
资助金额：

$32.96万
财政年份：

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负责人：

RANDALL Scott JOHNSON
依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

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批准号：

6747178
项目类别：
资助金额：

$0.6万
财政年份：

2004
负责人：

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依托单位：

KEYSTONE SYMPOSIA

CORE--ANIMAL EXPERIMENTATION RESOURCE

批准号：

6316513
项目类别：
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$10.6万
财政年份：

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负责人：

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依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

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批准号：

8053298
项目类别：
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$30.34万
财政年份：

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负责人：

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依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

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批准号：

7530436
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$31.39万
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UNIVERSITY OF CALIFORNIA, SAN DIEGO

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批准号：

7802264
项目类别：
资助金额：

$31.32万
财政年份：

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依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

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批准号：

6192393
项目类别：
资助金额：

$10.6万
财政年份：

1999
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RANDALL Scott JOHNSON
依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

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批准号：

8248592
项目类别：
资助金额：

$21.52万
财政年份：

1999
负责人：

RANDALL Scott JOHNSON
依托单位：

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批准号：

7228230
项目类别：
资助金额：

$30.48万
财政年份：

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负责人：

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依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

海外基金

Boosting Innate Immunity Through HIF to Treat Drug-Resistant Bacterial Infections

项目成果

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