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PINK1 Regulation of Neuronal and Mitochondrial Homeostasis

PINK1 Regulation of Neuronal and Mitochondrial Homeostasis
PINK1 对神经元和线粒体稳态的调节
批准号：
8089006
负责人：
Charleen T Chu
金额：
$37.88万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-07-15 至 2011-07-14
来源：
https://reporter.nih.gov/project-details/8089006
关键词：
1-Methyl-4-phenylpyridiniumAffectAutophagocytosisBiologicalCell DeathCell LineCellsCellular biologyCyclic AMP-Dependent Protein KinasesDataDiseaseDisease modelGeneticGoalsHealthHomeostasisHumanInjuryIntoxicationKnock-outKnockout MiceKnowledgeLeadLightMAP1 Microtubule-Associated ProteinMaintenanceMass Spectrum AnalysisMediatingMediator of activation proteinMitochondriaModelingMutationNerve DegenerationNeuritesNeurodegenerative DisordersNeuronal DysfunctionNeuronal InjuryNeuronsOxidopaminePTEN-induced putative kinaseParkinson DiseaseParkinsonian DisordersPathway interactionsPhosphorylationPhosphorylation SitePhosphotransferasesProteomicsPublic HealthRecessive Parkinsonism, AutosomalRegulationRoleSignal PathwaySignal TransductionStressStructureSynapsesSystemTestingTherapeuticToxinYangabstractingbasebrain tissuein vivoinsightleucine-rich repeat kinase 2loss of function mutationmitochondrial dysfunctionneuron lossneuroprotectionnew therapeutic targetnovel therapeuticsoverexpressionpreventsynaptic function

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