PINK1 Regulation of Neuronal and Mitochondrial Homeostasis

PINK1 对神经元和线粒体稳态的调节

• 批准号: 8089006
• 负责人: Charleen T Chu
• 金额: $ 37.88万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-15 至 2011-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8089006
• 关键词: 1-Methyl-4-phenylpyridinium; Affect; Autophagocytosis; Biological; Cell Death; Cell Line; Cells; Cellular biology; Cyclic AMP-Dependent Protein Kinases; Data; Disease; Disease model; Genetic; Goals; Health; Homeostasis; Human; Injury; Intoxication; Knock-out; Knockout Mice; Knowledge; Lead; Light; MAP1 Microtubule-Associated Protein; Maintenance; Mass Spectrum Analysis; Mediating; Mediator of activation protein; Mitochondria; Modeling; Mutation; Nerve Degeneration; Neurites; Neurodegenerative Disorders; Neuronal Dysfunction; Neuronal Injury; Neurons; Oxidopamine; PTEN-induced putative kinase; Parkinson Disease; Parkinsonian Disorders; Pathway interactions; Phosphorylation; Phosphorylation Site; Phosphotransferases; Proteomics; Public Health; Recessive Parkinsonism, Autosomal; Regulation; Role; Signal Pathway; Signal Transduction; Stress; Structure; Synapses; System; Testing; Therapeutic; Toxin; Yang; abstracting; base; brain tissue; in vivo; insight; leucine-rich repeat kinase 2; loss of function mutation; mitochondrial dysfunction; neuron loss; neuroprotection; new therapeutic target; novel therapeutics; overexpression; prevent; synaptic function