The effects of Nlrp12 and IL-1b in inflammatory disorders

Nlrp12 和 IL-1b 在炎症性疾病中的作用

• 批准号: 8077002
• 负责人: Kristi L Williams
• 金额: $ 39.25万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8077002
• 关键词: Adaptor Signaling Protein; Allergens; Amino Acids; Asthma; Biochemical; Caspase-1; Cell Count; Cells; Cleaved cell; Clinical; Clinical Treatment; Complex; Cryptococcus; Data; Dendritic Cells; Development; Disease; Environment; Etiology; Event; Fever; Goals; Gout; Hereditary Periodic Fever Syndromes; House mice; Human; Hyperactive behavior; Immune response; Immunology; Infection; Inflammation; Inflammatory; Inherited; Insulin-Dependent Diabetes Mellitus; Interleukin-1; Interleukin-17; Interleukin-18; Intervention; Lead; Lung; Lung Inflammation; Mediating; Modeling; Mus; Mutation; Mycoses; Myeloid Cells; Non-Insulin-Dependent Diabetes Mellitus; Pathology; Patients; Pharmaceutical Preparations; Phenotype; Process; Production; Proteins; Publishing; Refractory; Relative (related person); Reporting; Risk; Series; Signal Transduction; Stimulus; Syndrome; T cell response; T-Lymphocyte; Tertiary Protein Structure; Testing; Tissues; Wild Type Mouse; abstracting; airway hyperresponsiveness; base; cell injury; cytokine; functional restoration; human morbidity; in vivo; insight; loss of function mutation; lymph nodes; macrophage; member; monocyte; mutant; novel; overexpression; pathogen; protein complex; response; sensor

项目成果

The inflammasome regulatory pathway and infections: role in pathophysiology and clinical implications.

• DOI: 10.1016/j.jinf.2010.10.002
• 发表时间: 2011-02
• 期刊: The Journal of infection
• 作者: R. Osawa;K. Williams;Nina Singh