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Cyclic nucleotide signaling and the modulation of asthma inflammatory responses

Cyclic nucleotide signaling and the modulation of asthma inflammatory responses
环核苷酸信号传导和哮喘炎症反应的调节
批准号：
8076444
负责人：
Marco Conti
金额：
$38.63万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-06-21 至 2012-03-01
来源：
https://reporter.nih.gov/project-details/8076444
关键词：
1p31AblationAdoptive TransferAffectAllelesAllergensAnti-Inflammatory AgentsAnti-inflammatoryAntigen PresentationAntigensAsthmaCell Differentiation processCell Surface ProteinsCellsCodeComplexCyclic AMPCyclic NucleotidesDataDendritic CellsDevelopmentDiseaseDistalDrug IndustryEnvironmentEnzymesExperimental ModelsExposure toExtrinsic asthmaFoundationsGene SilencingGenesGeneticGoalsHomeostasisHumanHuman GenomeImmuneImmune systemImmunoprecipitationIn VitroInflammationInflammatoryInflammatory ResponseKnockout MiceLigationLightLungMacromolecular ComplexesMessenger RNAMolecularMusPDE4BPathogenesisPharmaceutical PreparationsPhenotypePhosphodiesterase InhibitorsPhysiologicalPlayPneumoniaProductionProtein IsoformsRegulationRegulatory PathwayRegulatory T-LymphocyteRhinitisRoleSignal TransductionSteroidsT-Cell ReceptorT-LymphocyteTLR4 geneTNF geneTestingTh2 CellsTherapeuticToll-like receptorsTransgenic Organismsairway hyperresponsivenessairway inflammationbasecytokinedesignimmunoregulationin vivoinhibitor/antagonistlymph nodesmigrationmouse developmentmouse modelnovelnovel therapeuticsoverexpressionphosphodiesterase IVphosphoric diester hydrolasepreventprogramsresearch studyresponse

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