Cyclic nucleotide signaling and the modulation of asthma inflammatory responses

环核苷酸信号传导和哮喘炎症反应的调节

• 批准号: 8076444
• 负责人: Marco Conti
• 金额: $ 38.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-21 至 2012-03-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076444
• 关键词: 1p31; Ablation; Adoptive Transfer; Affect; Alleles; Allergens; Anti-Inflammatory Agents; Anti-inflammatory; Antigen Presentation; Antigens; Asthma; Cell Differentiation process; Cell Surface Proteins; Cells; Code; Complex; Cyclic AMP; Cyclic Nucleotides; Data; Dendritic Cells; Development; Disease; Distal; Drug Industry; Environment; Enzymes; Experimental Models; Exposure to; Extrinsic asthma; Foundations; Gene Silencing; Genes; Genetic; Goals; Homeostasis; Human; Human Genome; Immune; Immune system; Immunoprecipitation; In Vitro; Inflammation; Inflammatory; Inflammatory Response; Knockout Mice; Ligation; Light; Lung; Macromolecular Complexes; Messenger RNA; Molecular; Mus; PDE4B; Pathogenesis; Pharmaceutical Preparations; Phenotype; Phosphodiesterase Inhibitors; Physiological; Play; Pneumonia; Production; Protein Isoforms; Regulation; Regulatory Pathway; Regulatory T-Lymphocyte; Rhinitis; Role; Signal Transduction; Steroids; T-Cell Receptor; T-Lymphocyte; TLR4 gene; TNF gene; Testing; Th2 Cells; Therapeutic; Toll-like receptors; Transgenic Organisms; airway hyperresponsiveness; airway inflammation; base; cytokine; design; immunoregulation; in vivo; inhibitor/antagonist; lymph nodes; migration; mouse development; mouse model; novel; novel therapeutics; overexpression; phosphodiesterase IV; phosphoric diester hydrolase; prevent; programs; research study; response