Blockade of the SDF-1/CXCR4 axis as a novel strategy for mitigating radiation-ind

封锁 SDF-1/CXCR4 轴作为减轻辐射的新策略

• 批准号: 7586528
• 负责人: HYUNSUK SHIM
• 金额: $ 85.03万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-14 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7586528
• 关键词: Adverse effects; Alveolar; Area; Binding; Biological Availability; Bleomycin; Bone Marrow; Breathing; CXCR4 Receptors; CXCR4 gene; Caring; Cells; Chemotaxis; Clinical Trials; Deposition; Development; Dose; Drug usage; Exposure to; Fibrosis; Goals; Injury; Ionizing radiation; Lung; Medical; Oral; Outcome; Particulate; Patients; Pharmaceutical Preparations; Play; Prevention; Process; Pulmonary Fibrosis; Radiation; Radioactive; Role; Shortness of Breath; Stem cells; Stromal Cell-Derived Factor 1; Structure; Therapeutic; Toxic effect; Work; base; chemokine; chemotherapy; inhibitor/antagonist; injured; interstitial; irradiation; lung development; lung injury; mouse model; novel strategies; radiation effect; research clinical testing; response

项目成果

Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis.

• DOI: 10.1371/journal.pone.0079768
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Shu HK;Yoon Y;Hong S;Xu K;Gao H;Hao C;Torres-Gonzalez E;Nayra C;Rojas M;Shim H
• 通讯作者: Shim H