Feasibility Study of the ACT (Active Cancellation of Tremor) Device

ACT（主动消除震颤）装置的可行性研究

• 批准号: 7906546
• 负责人: Anupam Pathak
• 金额: $ 15.93万
• 依托单位: LYNX DESIGN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2011-05-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7906546
• 关键词: Abate; Adrenergic beta-Antagonists; Affect; Age; Alloys; Arts; Boston; Categories; Consumption; Deep Brain Stimulation; Development; Devices; Disease; Eating; Eating Utensils; Effectiveness; Elderly; Electromagnetics; Electronics; Ensure; Essential Tremor; Feasibility Studies; Foundations; Freedom; Frequencies; Future; Generations; Genus Lynx; Goals; Hand; Housing; Human; Human Volunteers; Individual; Intellectual Property; International; Knowledge; Licensing; Life; Marketing; Medical Device; Memory; Michigan; Motion; Movement; Muscle; Occupations; Onset of illness; Operative Surgical Procedures; Pain; Patients; Persistent Tremors; Persons; Pharmaceutical Preparations; Pharmacological Treatment; Phase; Population; Prevalence; Production; Prosthesis; Quality of life; Rights; Risk; Running; Self-Help Devices; Shapes; Small Business Innovation Research Grant; Social isolation; Solutions; Source; Stroke; Surgeon; System; Technology; Testing; Therapeutic; Time; Tremor; Universities; Weight; Work; artist; base; cost; daily functioning; design; disability; drinking; experience; grasp; human old age (65+); improved; interest; meetings; member; model design; monitoring device; musician; nervous system disorder; operation; patient population; practical application; prototype; public health relevance; research and development; sensor; success; technological innovation; tool

DESCRIPTION (provided by applicant): Essential Tremor (ET) is the single most common motion disorder, affecting 10 million people in the US alone. Due to the debilitating muscle movements associated with this disease, people with ET have difficulty in performing daily functions such as eating and drinking and as a result often become socially isolated. Many individuals are also forced to retire from their occupations. Unfortunately, current pharmacological treatments have limited effectiveness in abating the condition, and surgical procedures can be expensive and invasive. To fill the needs of those who suffer from persistent tremor, Lynx Design is investigating a cost-effective, lightweight, hand-held stabilization device. In Phase I, Lynx Design proposes to develop a state-of-the-art actuator/controller system for a hand-held ACT (Active Cancellation of Tremor) device, and to demonstrate feasibility in a proof-of-concept prototype. Lynx Design will evaluate three possible actuator technologies- shape memory alloys, piezoelectrics, and electromagnetic actuators-and experimentally characterize the one found to be most suitable for the application. Lynx Design will then model, design, and build a prototype synthesizing this actuator with an embedded sensor and micro-controller to form a closed-loop system with the capability to stabilize ET. To demonstrate product feasibility, the resulting miniature actuator, sensor, and controller will be incorporated in a hand-held proof-of-concept device. Phase II work will focus on refining the ACT technology with patient input to create a commercial product. At the end of Phase II, Lynx Design will be ready to launch this highly portable, handheld product into the growing assistive device market, providing a far- reaching solution that positively impacts quality of life for a growing population of ET sufferers. ) PUBLIC HEALTH RELEVANCE: Lynx Design proposes to develop an active tremor cancellation technology that will assist individuals affected by Stroke or motion disorders such as Essential Tremor. It is Lynx Design's hope that these devices will reduce potential for social isolation, improve quality of life, and re-enable the affected public to participate in occupations that were lost upon disease onset.

描述(申请人提供)：基本震颤(ET)是最常见的一种运动障碍，仅在美国就有1000万人受到影响。由于与这种疾病相关的衰弱肌肉运动，患有ET的人难以执行日常功能，如吃和喝，因此经常成为社交孤立的人。许多人也被迫从他们的职业中退休。不幸的是，目前的药物治疗在缓解这种情况方面的效果有限，而且外科手术可能是昂贵的和侵入性的。为了满足持续性震颤患者的需求，Lynx Design正在研究一种性价比高、重量轻的手持稳定装置。在第一阶段，Lynx Design计划为手持式ACT(有源消除震颤)设备开发一种最先进的执行器/控制器系统，并在概念验证原型中证明其可行性。Lynx Design将评估三种可能的致动器技术-形状记忆合金、压电和电磁致动器-并通过实验表征发现最适合应用的一种技术。然后，Lynx Design将建模、设计和构建一个原型，将该执行器与嵌入式传感器和微控制器合成，以形成具有稳定ET能力的闭环系统。为了证明产品的可行性，所产生的微型致动器、传感器和控制器将被整合到手持概念验证设备中。第二阶段的工作将专注于通过患者的输入来完善ACT技术，以创造出一种商业产品。在第二阶段结束时，Lynx Design将准备向不断增长的辅助设备市场推出这种高度便携的手持产品，提供一个影响深远的解决方案，对日益增长的ET患者的生活质量产生积极影响。) 与公共健康相关：Lynx Design建议开发一种主动震颤消除技术，该技术将帮助受中风或运动障碍影响的个人，如基本震颤。Lynx Design希望这些设备将减少社会隔离的可能性，提高生活质量，并使受影响的公众重新参与到疾病发作时失去的职业中。