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Development of an Active Cancellation of Tremor (ACT) System for Human Assistance

开发用于人类援助的主动震颤消除 (ACT) 系统

基本信息

批准号：
8307768
负责人：
Anupam Pathak
金额：
$ 32.37万
依托单位：
LYNX DESIGN
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-15 至 2013-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8307768
关键词：
Abate Affect Anxiety Clinical Clinical Research Development Devices Disease Eating Eating Utensils Effectiveness Elderly Ensure Essential Tremor Extravasation Failure Feedback Future Genus Lynx Goals Grant Hand Home environment Human Individual Information Technology Laboratories Life Liquid substance Marketing Motion Movement Movement Disorders Muscle Occupations Onset of illness Operative Surgical Procedures Patients Pharmacological Treatment Phase Population Problem Solving Quality of life Research Role Running Safety Self-Help Devices Small Business Innovation Research Grant Social isolation System Technology Technology Transfer Testing Time Tremor United States National Institutes of Health Visual Work Writing base commercialization cost cost effective daily functioning design drinking heuristics human data impression improved novel operation prevent prototype research and development sensor tool

项目摘要

DESCRIPTION (provided by applicant): Essential Tremor (ET) is the single most common motion disorder, affecting 10 million people in the US alone. Due to the debilitating muscle movements associated with this disease, people with ET have difficulty in performing daily functions such as eating and drinking. As a result, many people become socially isolated and are also forced to retire from occupations held before the disease onset. Unfortunately, current pharmacological treatments have limited effectiveness in abating tremor, and surgical procedures can be expensive and invasive. To solve this problem, Lynx Design is investigating a cost-effective, lightweight, hand- held stabilization device called the ACT (Active Cancellation of Tremor) system. During Phase I work, a state- of-the-art hand-held prototype was developed and tested, demonstrating a reduction of tremor disturbances by up to 80% (for 1-2 cm). This result exceeded Phase I goals for technical feasibility and showed promise for future applications. Proposed Phase II work will focus on developing the ACT system further through a combination of clinical research and R&D. Key developments will focus on: 1) demonstrating/characterizing the technology's efficacy 2) improving control and long-term reliability and 3) designing the system for general use in daily activities (based on patient feedback). Detailed plans to commercialize the ACT system in the growing assistive device market are in place and will be executed after the Phase II work. The resulting distribution of the ACT technology will impact the growing population of ET sufferers, positively impacting their quality of life.

描述（由申请人提供）：特发性震颤（ET）是最常见的运动障碍，仅在美国就有1000万人受到影响。由于与这种疾病相关的衰弱性肌肉运动，ET患者难以执行日常功能，如饮食。因此，许多人在社会上变得孤立，并被迫从发病前从事的职业中退休。不幸的是，目前的药物治疗在减轻震颤方面的有效性有限，并且外科手术可能是昂贵的和侵入性的。为了解决这个问题，Lynx Design正在研究一种成本效益高、重量轻的手持式稳定装置，称为ACT（主动消除震颤）系统。在第一阶段工作期间，开发并测试了最先进的手持式原型，证明震颤干扰减少高达80%（对于1-2 cm）。这一结果超过了第一阶段的技术可行性目标，并显示出未来应用的前景。拟议的第二阶段工作将侧重于通过临床研究和研发相结合进一步开发ACT系统。关键的发展将集中在：1）展示/表征该技术的功效2）改善控制和长期可靠性和3）设计系统用于日常活动（基于患者反馈）。在不断增长的辅助器具市场上将ACT系统商业化的详细计划已经到位，并将在第二阶段工作之后执行。ACT技术的分布将影响不断增长的ET患者人口，对他们的生活质量产生积极影响。