Development of a Thin-Film MicroECOG Electrode for Chronic Cortical Recordings

用于慢性皮质记录的薄膜 MicroECOG 电极的开发

• 批准号: 8111138
• 负责人: Daniel William Moran
• 金额: $ 49.2万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111138
• 关键词: Affect; Amyotrophic Lateral Sclerosis; Area; Behavioral; Behavioral Paradigm; Biofeedback; Blood - brain barrier anatomy; Brain; Brain region; Caliber; Chronic; Clinical; Communication; Computers; Cortical Column; Custom; Data; Development; Devices; Dorsal; Electrocorticogram; Electrodes; Epilepsy; Equipment; Film; Frequencies; Goals; Health; Histology; Histopathology; Human; Implant; Individual; Infection; Iron; Knowledge; Lead; Limb structure; Macaca mulatta; Mechanics; Meningitis; Microelectrodes; Modality; Monitor; Motor; Motor Cortex; Mus; Neuraxis; Neuromuscular Diseases; Neuronal Plasticity; Operative Surgical Procedures; Outcome; Paralysed; Penetration; Performance; Polymers; Primates; Process; Property; Research; Research Project Grants; Robotics; Seizures; Signal Transduction; Site; Speed; Spinal cord injury; Staging; Surface; System; Technology; Testing; Time; Tissues; Training; Trephine hole; Wheelchairs; base; brain computer interface; clinical application; design; flexibility; functional restoration; human subject; implantable device; implantation; interest; millimeter; mind control; neuroadaptation; neurophysiology; nonhuman primate; novel; research study; tool; two-dimensional; virtual reality

DESCRIPTION (provided by applicant): Our primary research interest is in the area of motor neuroprosthetics. We seek to restore function to those suffering from neuromuscular disease and/or paralysis. This study will design and test a novel implantable, epidural micro-electrocorticographic (uECoG) array capable of recording high gamma band activity from the brain for long periods of time (years). We have developed a novel behavioral paradigm in a non-human primate virtual reality simulator to test and optimize the uECoG design. This neuroprosthetic research project will develop the knowledge, tools, and equipment needed to enable paralyzed individuals to control a computer cursor, wheelchair or robotic limb. The specific aims of this project are to 1) Develop and bench-test 5ECoG electrode array and implantable device platform; 2) Determine the optimal electrode diameters and inter-electrode spacings for both open-loop and closed-loop chronic recordings of gamma band activity over motor cortical regions in the non-human primate brain using an epidural 5ECoG electrode; and 3) Determine the optimal epidural 5ECoG signal parameters (i.e. center frequency and bandwidth) and motor cortical region (M1, Pmv, Pmd) for closed-loop BCI control of a computer cursor. PUBLIC HEALTH RELEVANCE: This project will design and test a novel, implantable, thin-film, epidural micro-electrocorticographic electrode array that will allow long-term chronic recording of brain activity. This new electrode design will be optimized for use in a brain-computer interface system that will allow paralyzed individuals to accurately control a computer mouse via direct brain control.

描述(申请人提供)：我们的主要研究兴趣是在运动神经假体领域。我们寻求恢复那些患有神经肌肉疾病和/或瘫痪的人的功能。这项研究将设计和测试一种新型的可植入的硬膜外显微皮质脑电图仪(UECoG)阵列，能够长时间(数年)记录大脑的高伽马频段活动。我们在一个非人类灵长类动物虚拟现实模拟器中开发了一种新的行为范式来测试和优化uECoG设计。这个神经假体研究项目将开发所需的知识、工具和设备，使瘫痪的人能够控制计算机光标、轮椅或机械臂。该项目的具体目标是1)开发和台架测试5ECoG电极阵列和植入式设备平台；2)确定使用硬膜外5ECoG电极对非人类灵长类动物大脑运动皮质区域伽马带活动的开环和闭环慢性记录的最佳电极直径和电极间间距；以及3)确定用于计算机光标的闭环BCI控制的最佳硬膜外5ECoG信号参数(即中心频率和带宽)和运动皮质区域(M1、PMV、PMD)。与公共健康相关：该项目将设计和测试一种新型的、可植入的、薄膜的、硬膜外微皮质脑电电极阵列，该电极阵列将允许长期长期记录大脑活动。这种新的电极设计将被优化用于脑-计算机接口系统，该系统将允许瘫痪的人通过直接的大脑控制准确地控制计算机鼠标。

项目成果

Evaluation of cancer stem cell migration using compartmentalizing microfluidic devices and live cell imaging.

• DOI: 10.3791/3297
• 发表时间: 2011-12-23
• 期刊: Journal of visualized experiments : JoVE
• 作者: Huang Y;Agrawal B;Clark PA;Williams JC;Kuo JS
• 通讯作者: Kuo JS

Spatial differences in corneal electroretinogram potentials measured in rat with a contact lens electrode array.

• DOI: 10.1007/s10633-014-9459-5
• 发表时间: 2014-12
• 期刊: DOCUMENTA OPHTHALMOLOGICA
• 影响因子: 1.4
• 作者: Krakova, Yelena;Tajalli, Hadi;Thongpang, Sanitta;Derafshi, Zahra;Ban, Tamas;Rahmani, Safa;Selner, Ashley N.;Al-Tarouti, Amani;Williams, Justin C.;Hetling, John R.
• 通讯作者: Hetling, John R.

Advanced Materials for Neural Surface Electrodes.

用于神经表面电极的先进材料。

• DOI: 10.1016/j.cossms.2014.09.006
• 发表时间: 2014
• 期刊: Current opinion in solid state & materials science
• 影响因子: 11
• 作者: Schendel,AmeliaA;Eliceiri,KevinW;Williams,JustinC
• 通讯作者: Williams,JustinC

Evolution of brain-computer interface: action potentials, local field potentials and electrocorticograms.

大脑计算机界面的演变：动作电位，局部场电位和皮肤图。

• DOI: 10.1016/j.conb.2010.09.010
• 发表时间: 2010-12
• 期刊: Current opinion in neurobiology
• 影响因子: 5.7
• 作者: Moran D

Mechanical actuation of ion channels using a piezoelectric planar patch clamp system.

使用压电平面膜片钳系统机械驱动离子通道。

• DOI: 10.1039/c1lc20636b
• 发表时间: 2012
• 期刊: Lab on a chip
• 影响因子: 6.1
• 作者: Stava,Eric;Yu,Minrui;Shin,HyunCheol;Shin,Hyuncheol;Rodriguez,Jonathan;Blick,RobertH
• 通讯作者: Blick,RobertH