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Molecular Imaging of Cardiac Hypertrophy Using microPET and Pinhole SPECT

使用 microPET 和针孔 SPECT 进行心脏肥大的分子成像

基本信息

批准号：
8069862
负责人：
GRANT T GULLBERG
金额：
$ 72.63万
依托单位：
UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-15 至 2013-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8069862
关键词：
Adrenergic Agents Affect Age Algorithms Anatomy Animal Experiments Animals Beds Biochemical Blood Blood Circulation Calibration Cardiac Cause of Death Clinic Clinical Collagen Collimator Communities Computer Simulation Congestive Heart Failure Data Databases Detection Development Diagnosis Diffusion Magnetic Resonance Imaging Disease Electrocardiogram Elements Factor Analysis Fatty Acids Fiber Functional disorder Gelatinases Glucose Goals Heart Heart Hypertrophy Heart failure Histopathology Human Hypertension Image Imaging technology Inbred SHR Rats Kinetics Magnetic Resonance Magnetic Resonance Imaging Measures Mechanics Metabolism Metalloproteases Methods Mining Modeling Molecular Monitor Motion Myocardium Patients Penetration Perfusion Physiological Positioning Attribute Positron-Emission Tomography Process Property Protocols documentation Radioisotopes Radiopharmaceuticals Rattus Relative (related person)Retinal Cone Rotation Sampling Severities Structure Subtraction Technique System Techniques Technology Testing Time Tracer Translating adrenergic aging population attenuation base collagenase density design detector glucose metabolism improved innovation instrument molecular imaging nerve supply new technology reconstruction response simulation single photon emission computed tomography spatiotemporal technique development technology development tomography tool uptake

项目摘要

DESCRIPTION (provided by applicant): Congestive heart failure (CHF), a major cause of death in the US, is a growing problem in our aging population. This proposed project is directed at developing radionuclide molecular imaging technologies using a clinical pinhole SPECT/CT scanner to quantify the changes in deformation, perfusion, innervation, and metabolism in the heart using the spontaneous hypertensive rat (SHR) as a model of hypertensive related pathophysiology. The similarity in the response to CHF treatment for humans and for SHR suggests that the SHR is an appropriate model for a major class of heart failures that are due to hypertension. The combined application of both microPET and pinhole SPECT provides tools to improve and evaluate developed technology. In addition, ex vivo magnetic resonance diffusion tensor imaging, simultaneous PET/MRI, and histopathology will provide mechanical and biochemical structural correlates. Preliminary data using the SHR model indicate that such technological developments are possible. The new technologies will improve diagnosis, monitor progression, and evaluate therapy for the disease. Because our technological approach uses pinhole clinical SPECT/CT and radiopharmaceuticals that reflect flow, metabolism, innervation, and structural mechanics, the developed techniques can be directly translated to clinical instruments for better management of patients with heart failure. The uniqueness of this project is the development of techniques for estimating input function from projections of a slow rotating camera imaging fast circulation in a rat, the application of mechanical models to detect early changes in deformation in the hypertrophied heart, and the quantification of the kinetics of tracers using models of the image detection process in which the effects of attenuation, scatter, and collimator response are determined from Monte Carlo simulations. Combining new dynamic and conventional clinical imaging protocols with improved descriptions of the heart (physiological, mechanical, and biochemical) will allow us to obtain better specification of the heart's properties and to study how molecular changes in the heart caused by disease affect these properties. Innovations for pinhole-based tomography of animals that are useful to the scientific community are collimator design, gantry motion calibration, reconstruction algorithms for cone beam geometry, and spatiotemporal modeling of attenuation and scatter. The development of these technologies will provide methods for quantifying perfusion, biochemical kinetics, and wall dynamics.

描述（由申请人提供）：充血性心力衰竭（CHF）是美国的主要死亡原因，在我们的老龄化人口中是一个日益严重的问题。本研究拟以自发性高血压大鼠（SHR）为高血压相关病理生理学模型，利用临床针孔SPECT/CT扫描仪，研究放射性核素分子成像技术，定量研究心脏的变形、灌注、神经支配和代谢变化。人类和SHR对CHF治疗的反应相似，表明SHR是高血压所致心力衰竭主要类别的适当模型。microPET和针孔SPECT的联合应用为改进和评估已开发的技术提供了工具。此外，离体磁共振扩散张量成像、同步PET/MRI和组织病理学将提供机械和生物化学结构相关性。使用SHR模型的初步数据表明，这种技术发展是可能的。新技术将改善诊断，监测进展，并评估疾病的治疗。由于我们的技术方法使用针孔临床SPECT/CT和放射性药物，反映血流，代谢，神经支配和结构力学，因此开发的技术可以直接转化为临床仪器，以更好地管理心力衰竭患者。该项目的独特之处在于开发了用于从缓慢旋转的相机成像大鼠快速循环的投影中估计输入函数的技术，应用机械模型来检测肥大心脏中变形的早期变化，以及使用图像检测过程的模型来量化示踪剂的动力学，其中衰减，散射，和准直器响应由蒙特卡罗模拟确定。将新的动态和常规临床成像方案与改进的心脏描述（生理、机械和生化）相结合，将使我们能够获得更好的心脏特性规范，并研究疾病引起的心脏分子变化如何影响这些特性。对科学界有用的基于针孔的动物断层扫描的创新是准直器设计、机架运动校准、锥形束几何形状的重建算法以及衰减和散射的时空建模。这些技术的发展将提供定量灌注，生化动力学和壁动力学的方法。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Longitudinal Evaluation of Sympathetic Nervous System and Perfusion in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic Single-Photon Emission Computed Tomography.

使用动态单光子发射计算机断层扫描对正常和自发性高血压大鼠心脏的交感神经系统和灌注进行纵向评估。

DOI：
发表时间：
2015
期刊：
Molecular Imaging
影响因子：
2.8
作者：
Huang, Qiu;Li, Biao;Chen, Kewei;Gullberg, Grant T
通讯作者：
Gullberg, Grant T

Longitudinal Evaluation of Myocardial Fatty Acid and Glucose Metabolism in Fasted and Nonfasted Spontaneously Hypertensive Rats Using MicroPET/CT.

DOI：
10.1177/1536012117724558
发表时间：
2017-01
期刊：
Molecular imaging
影响因子：
2.8
作者：
Huber JS;Hernandez AM;Janabi M;O'Neil JP;Brennan KM;Murphy ST;Seo Y;Gullberg GT
通讯作者：
Gullberg GT

Quantitative analysis of hypertrophic myocardium using diffusion tensor magnetic resonance imaging.

使用扩散张量磁共振成像对肥厚心肌进行定量分析。