"Mechanisms underlying nicotine induced neuronal toxicity in zebrafish"

“尼古丁诱导斑马鱼神经元毒性的机制”

• 批准号: 8232087
• 负责人: KURT R SVOBODA
• 金额: $ 34.4万
• 依托单位: UNIVERSITY OF WISCONSIN MILWAUKEE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-03 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8232087
• 关键词: Acetylcholine; Address; Adult; Afferent Neurons; Age-Months; Agonist; Anatomy; Animals; Basic Science; Behavior; Behavioral; Birth; Cessation of life; Cholinergic Agonists; Chronic; Clinical; Cognitive; Complex; Coupled; Defect; Development; Embryo; Embryonic Development; Exhibits; Exposure to; Foundations; Goals; Health; Human; Human Development; Individual; Lead; Learning; Life; Link; Locomotion; Mediating; Memory; Modeling; Molecular Genetics; Morphology; Motor Neurons; Muscle; Muscle Development; Nervous system structure; Neurons; Nicotine; Nicotinic Receptors; Outcome; Paralysed; Phenotype; Physiological; Physiology; Positioning Attribute; Potato; Pregnancy; Pregnant Women; Role; Sensory; Smoke; Smoking; Spinal; Staging; Structure; Swimming; Techniques; Testing; Time; Toxic effect; Toxicogenetics; Woman; Work; Zebrafish; cell type; cholinergic; comparative genomics; drug of abuse; esterase; in vivo; insight; mature animal; mutant; neuromuscular; neuron development; neurotoxicity; neurotoxicology; premature; response; tool; zebrafish genome

项目成果

Acute nicotine exposure and modulation of a spinal motor circuit in embryonic zebrafish.

胚胎斑马鱼的急性尼古丁暴露和脊髓运动回路的调节。

• DOI: 10.1016/j.taap.2008.08.023
• 发表时间: 2009
• 期刊: Toxicology and applied pharmacology
• 影响因子: 3.8
• 作者: Thomas,LatoyaT;Welsh,Lillian;Galvez,Fernando;Svoboda,KurtR
• 通讯作者: Svoboda,KurtR

Embryonic motor activity and implications for regulating motoneuron axonal pathfinding in zebrafish.

• DOI: 10.1111/j.1460-9568.2008.06418.x
• 发表时间: 2008-09
• 期刊: The European journal of neuroscience
• 作者: Menelaou E;Husbands EE;Pollet RG;Coutts CA;Ali DW;Svoboda KR
• 通讯作者: Svoboda KR