Multilevel and Longitudinal Study Sample Size Tools for Behavioral Scientists
行为科学家的多层次和纵向研究样本量工具
基本信息
- 批准号:8041352
- 负责人:
- 金额:$ 51.89万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-12-09 至 2014-11-30
- 项目状态:已结题
- 来源:
- 关键词:African AmericanAlcohol dependenceAmericanBehavioralBehavioral ResearchBehavioral SciencesBindingCodes of EthicsCommunitiesCommunity TrialComplexComputer SimulationComputer softwareDataDental ResearchEducational process of instructingEthicsExhibitsFundingGoalsHead and Neck CancerHealthHealth behaviorHeartHumanJournalsKnowledgeLeadLongitudinal StudiesMalignant NeoplasmsMethodologyMethodsModelingMoralsNeckOperative Surgical ProceduresOutcome MeasureParticipantPatternPersonsPharyngeal structurePopulation HeterogeneityPreventionPrevention ResearchPublicationsPublishingResearchResearch DesignResourcesRisk FactorsSample SizeScienceScientistScreening procedureSocietiesSoftware DesignSpeedStructureTechniquesTestingTimeTobacco DependenceTrainingUnited States National Institutes of HealthWritingaddictionalcoholism preventioncostdesignhealth disparityimprovedlongitudinal designmanmeetingsmenmultilevel analysisonline tutorialopen sourcepreventresearch studytool
项目摘要
DESCRIPTION (provided by applicant): Current sample size methods for multilevel and longitudinal data often get the wrong answer. Studies that are too small cannot achieve scientific goals. Studies that are too large expose human research participants to unnecessary harm. The ethical codes that bind NIH funded behavioral scientists doing research with human participants demand correct sample size selection. Flaws of current sample size methods are a critical barrier to progress. Behavioral scientists use community trials, longitudinal data, and multilevel models to compare diverse populations. Understanding addiction and gauging knowledge about head and neck cancer screening require measuring outcomes over time. The complex data yield complex variance patterns. Current software (such as Optimal Design) makes simplifying assumptions about the variance patterns, which may lead to the wrong sample size. No available software always gives the correct sample size analysis; the existing paradigm fails. There are three barriers to progress in designing multilevel and longitudinal studies: 1) inadequate tools to evaluate when current sample size methods fail; 2) flawed methods and software to select sample size; and 3) insufficient training to find correct sample sizes. The successful completion of two aims will remove the three barriers. The aims are 1) Create new sample size methods and software needed to accurately mirror multilevel and longitudinal models of normal, binary, and Poisson data common in studying health behavior in diverse populations and 2) Train behavioral scientists to use the new methods and software. Training will include template sample size analyses, tutorial publications, short courses, webinars and online tutorials. Better sample size calculations will produce better designed studies. Better designed studies will speed ethical, efficient, and effective behavioral research. Behavioral research lies at the heart of preventing addiction and cancer. Correct sample size selection is not merely a statistical nicety. The new methods will directly improve the health of millions of Americans.
PUBLIC HEALTH RELEVANCE: The ethics and cost of human research demands accurate sample size. Current sample size selection methods can fail with multilevel and longitudinal data. We will develop new sample size tools for behavioral scientists conducting prevention research in communities with diverse populations.
描述(由申请人提供):目前针对多层次和纵向数据的样本大小方法往往会得到错误的答案。规模太小的研究无法达到科学目标。规模过大的研究使人类研究参与者受到不必要的伤害。约束NIH资助的行为科学家与人类参与者进行研究的道德准则要求正确的样本量选择。目前样本量方法的缺陷是取得进展的关键障碍。行为科学家使用社区试验、纵向数据和多层次模型来比较不同的人群。了解成瘾和衡量头颈癌筛查的知识需要衡量长期的结果。复杂的数据产生复杂的方差模式。当前的软件(如Optimal Design)简化了对方差模式的假设,这可能导致错误的样本量。没有可用的软件总是给出正确的样本大小分析;现有的范式失败了。在设计多水平和纵向研究方面存在三个障碍:1)当现有的样本量方法失败时,评估工具不足;2)样本量选择方法和软件存在缺陷;3)训练不足,无法找到正确的样本量。两个目标的成功实现将消除三个障碍。其目标是:1)创建新的样本量方法和软件,以准确反映研究不同人群健康行为中常见的正常、二进制和泊松数据的多层次和纵向模型;2)培训行为科学家使用新的方法和软件。培训将包括模板样本量分析、教程出版物、短期课程、网络研讨会和在线教程。更好的样本量计算将产生更好的设计研究。设计得更好的研究将加快道德、高效和有效的行为研究。行为研究是预防成瘾和癌症的核心。正确的样本量选择不仅仅是统计上的精确。这些新方法将直接改善数百万美国人的健康。
项目成果
期刊论文数量(0)
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Keith E Muller其他文献
Selecting a sample size for studies with repeated measures
- DOI:
10.1186/1471-2288-13-100 - 发表时间:
2013-07-31 - 期刊:
- 影响因子:3.400
- 作者:
Yi Guo;Henrietta L Logan;Deborah H Glueck;Keith E Muller - 通讯作者:
Keith E Muller
Keith E Muller的其他文献
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{{ truncateString('Keith E Muller', 18)}}的其他基金
Multilevel and Longitudinal Study Sample Size Tools for Behavioral Scientists
行为科学家的多层次和纵向研究样本量工具
- 批准号:
8578074 - 财政年份:2010
- 资助金额:
$ 51.89万 - 项目类别:
Multilevel and Longitudinal Study Sample Size Tools for Behavioral Scientists
行为科学家的多层次和纵向研究样本量工具
- 批准号:
8303697 - 财政年份:2010
- 资助金额:
$ 51.89万 - 项目类别:
Multilevel and Longitudinal Study Sample Size Tools for Behavioral Scientists
行为科学家的多层次和纵向研究样本量工具
- 批准号:
8391073 - 财政年份:2010
- 资助金额:
$ 51.89万 - 项目类别:
Multilevel and Longitudinal Study Sample Size Tools for Behavioral Scientists
行为科学家的多层次和纵向研究样本量工具
- 批准号:
8204724 - 财政年份:2010
- 资助金额:
$ 51.89万 - 项目类别:
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