GENETIC AND IMMUNOLOGICAL RISK FACTORS FOR AUTISM

自闭症的遗传和免疫风险因素

• 批准号: 8167279
• 负责人: PETER K. GREGERSEN
• 金额: $ 0.04万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167279
• 关键词: Address; Antibodies; Autistic Disorder; Biological; Clinical Data; Computer Retrieval of Information on Scientific Projects Database; Development; Fetus; Funding; Genetic; Grant; Immunologic Factors; Individual; Institution; Mothers; Mutation; Neurodevelopmental Disorder; Play; Protocols documentation; Research; Research Personnel; Resources; Risk Factors; Role; Sampling; Source; United States National Institutes of Health; base

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is directed to providing the clinical data and associated biological samples which will enable a broad based effort to identify genetic and immunological factors that cause autism and related neurodevelopmental disorders. Specific aim 1 will address the hypothesis that de novo genetic changes occur in autistic subjects, and that these changes can be causative when present in a permissive genetic background. Specific aim 2 will address the hypothesis that antibodies circulating in the mothers of autistic individuals can play a role in the development of autism as a result of exposure of the fetus to such antibodies during intrauterine development.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该方案旨在提供临床数据和相关的生物学样本，这将使基于广泛的努力确定引起自闭症和相关神经发育障碍的遗传和免疫学因素。特定的目标1将解决自闭症受试者中从头遗传变化发生的假设，并且在允许的遗传背景中存在这些变化可能是病因。具体目标2将解决以下假设：自闭症患者母亲循环的抗体可以在宫内发育过程中胎儿暴露于这种抗体的结果中在自闭症的发展中发挥作用。