GENETIC AND IMMUNOLOGICAL RISK FACTORS FOR AUTISM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该议定书旨在提供临床数据和相关的生物样本，这将使广泛的努力能够确定导致自闭症和相关神经发育障碍的遗传和免疫因素。具体目标1将解决这样的假设，即自闭症受试者发生从头开始的基因变化，并且当这些变化存在于允许的遗传背景中时，这些变化可能是原因。具体目标2将解决这样一种假设，即自闭症患者母亲中循环的抗体可以在自闭症的发展中发挥作用，这是由于胎儿在宫内发育过程中接触到这种抗体。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol is directed to providing the clinical data and associated biological samples which will enable a broad based effort to identify genetic and immunological factors that cause autism and related neurodevelopmental disorders. Specific aim 1 will address the hypothesis that de novo genetic changes occur in autistic subjects, and that these changes can be causative when present in a permissive genetic background. Specific aim 2 will address the hypothesis that antibodies circulating in the mothers of autistic individuals can play a role in the development of autism as a result of exposure of the fetus to such antibodies during intrauterine development.