AUTOIMMUNITY IN SISTERS OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) PATIENTS (SISSLE)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目标是招募400名35岁以下被诊断为系统性红斑狼疮的女性和至少一名未受影响的姐妹，通过问卷调查进行纵向随访，两年内每年抽血。目的是了解狼疮发展之前的临床前生物学和免疫学事件，并确定可以预测临床疾病未来发展的生物标志物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal is to enroll 400 females diagnosed with systemic lupus erythematosus under the age of 35 and at least one unaffected sister to be followed longitudinally with questionnaires, annual blooddraws over two years. Aim is to understand the preclinical biological and immunologicalevents that preceed the development of lupus and to identify biomarkers that can predict future development of clinical disease.