EXERCISE INTENSITY AND POST-PRANDIAL GLUCOSE DISPOSAL IN OBESE ADULTS

肥胖成人的运动强度和餐后血糖处理

• 批准号: 8167178
• 负责人: EUGENE Joseph BARRETT
• 金额: $ 1.87万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167178
• 关键词: Adult; Area Under Curve; Atherosclerosis; Biological Assay; Blood; Blood specimen; Cell physiology; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Dose; Exercise; Expenditure; Funding; Glucose; Grant; Individual; Institution; Insulin; Insulin Resistance; Measures; Modeling; Myocardial Infarction; Obesity; Output; Peptides; Protocols documentation; Randomized; Research; Research Personnel; Resources; Rest; Risk; Source; Stroke; Testing; Time; United States National Institutes of Health; Woman; glucose disposal; impaired glucose tolerance; insulin sensitivity; men; response; waist circumference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In individuals with impaired glucose tolerance, exacerbated post-prandial glycemic excursions occur with higher levels of both glucose and insulin in the blood for longer periods of time. Increasing evidence suggests that these exacerbated post-prandial excursions are closely associated with, and may be pre-disposing for, many of the complications associated with diabetes and insulin resistance, including atherosclerosis, myocardial infarction, and stroke. Exercise has been shown to reduce the risks associated with insulin resistance and is an effective means of reducing glycemic excursions and increasing insulin sensitivity. In the present study, we will examine the dose-response relationship between intensity of exercise at equal caloric output and the resultant glycemic effects, with the ultimate aim of identifying the minimum effective exercise intensity for the reduction of post-prandial glycemic excursions. Abdominally obese subjects (BMI > 30, waist circumference > 80 cm for women and > 94 cm for men) will be tested on the GCRC on 5 occasions: (1) - a baseline VO2 Peak / LT protocol to determine exercise intensities and (4) randomly assigned sessions at rest and at 3 differing exercise intensities (low, moderate, intense - exercise duration will vary so that caloric expenditure can be constant for each exercise session at 250 kcal). During tests 2-5, seventy five grams of glucose will be administered 1 h after the onset of exercise. Blood samples will be collected at -30, -20 -10, 0, and at 5-10 minute intervals after the onset of exercise for 240 min and assayed for glucose, insulin and c-peptide. Glucose and insulin rate of change and area under the curve will be calculated. Minimal modeling will be used to assess glucose disposal and insulin sensitivity, and c-peptide minimal model will be used to evaluate -cell function. Repeated measures ANCOVA with covariate SI will be used to examine differences among conditions.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在葡萄糖耐量受损的个体中，随着血液中葡萄糖和胰岛素水平的升高，餐后血糖波动会加剧，持续时间更长。越来越多的证据表明，这些加剧的餐后波动与许多与糖尿病和胰岛素抵抗相关的并发症密切相关，并可能是这些并发症的诱因，包括动脉粥样硬化、心肌梗死和中风。运动已被证明可以降低与胰岛素抵抗相关的风险，是减少血糖波动和增加胰岛素敏感性的有效手段。在本研究中，我们将研究在相同的热量输出和由此产生的血糖效应的运动强度之间的剂量反应关系，最终目的是确定最低有效的运动强度，减少餐后血糖波动。腹部肥胖受试者（BMI > 30，女性腰围> 80 cm，男性腰围> 94 cm）将在GCRC上测试5次：（1）-基线VO 2峰值/ LT方案，以确定运动强度;（4）随机分配休息时和3种不同运动强度的训练（低、中、高强度-运动持续时间会有所不同，因此每次运动的热量消耗可以恒定在250千卡）。在测试2-5期间，将在运动开始后1小时给予75克葡萄糖。在开始运动240 min后，在-30、-20-10、0和5-10 min间隔采集血样，并测定葡萄糖、胰岛素和c肽。将计算葡萄糖和胰岛素的变化率和曲线下面积。最小模型将用于评估葡萄糖处置和胰岛素敏感性，c肽最小模型将用于评估β细胞功能。将使用具有协变量SI的重复测量ANCOVA检查条件之间的差异。