MENTAL PRACTICE IMPACT ON GAIT AND CORTICAL ORGANIZATION IN SPINAL CORD INJURY

心理练习对脊髓损伤患者步态和皮质组织的影响

• 批准号: 8166941
• 负责人: SUCHA KIM
• 金额: $ 1.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8166941
• 关键词: Ankle; Biological Markers; Complementary and alternative medicine; Computer Retrieval of Information on Scientific Projects Database; Data; Enrollment; Functional Magnetic Resonance Imaging; Funding; Gait; Grant; Hospitals; Individual; Institution; Leg; Methods; Mind-Body Intervention; Modality; Motor; Movement; Outcome Measure; Paralysed; Performance; Randomized; Recovery; Regimen; Rehabilitation therapy; Research; Research Personnel; Resources; Site; Source; Spinal cord injury; Spinal cord injury patients; Training; United States National Institutes of Health; Universities; Walking; gait examination; improved; kinematics; mental practice; motor skill learning; muscular structure; primary outcome; programs; relating to nervous system; skills

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the fundamental desire to walk after spinal cord injury (SCI), no conventional rehabilitation regimen has reliably shown to improve functional ambulation. Mental practice (MP) is a complementary/alternative medicine (CAM) mind-body technique in which physical skills can be cognitively rehearsed in a safe, repetitive manner. Additionally, MP increases motor skill learning and performance by activating the same neural and muscular structures when movements are mentally practiced as during physical practice of the same skills. Pilot data suggests that a rehabilitation program including MP increases gait velocity and leg movement in people with motor incomplete SCI. The purpose of this study is to show that MP participation renders a functional effect in ambulation training and validate ankle dorsiflexion as a neural biomarker of ambulation recovery using functional MRI (F MRI) by using randomized controlled methods. This multi-center study will be conducted at 2 academic centers: Drake Rehabilitation Hospital at the University of Cincinnati will serve as the primary study center and UC Irvine will serve as the secondary study center. The complete study will randomize a total of 32 individuals with motor incomplete SCI to either: (1) 30-minute MP sessions combined with locomotor training; or (2) conventional locomotor training only. At each study site, 16 subjects with SCI and 8 healthy subjects without SCI will be enrolled. The randomized comparison of subjects will help determine the functional impact of a gait training regimen including MP in SCI patients with impaired ambulation due to paralysis. Gait analysis modalities and F MRI will measure the outcomes variables including gait velocity (primary outcome), gait kinematics, and active voluntary leg and ankle movement.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管脊髓损伤(SCI)后的基本愿望是行走，但没有传统的康复疗法能够可靠地改善功能性行走能力。心理练习(MP)是一种补充/替代医学(CAM)心身技术，在这种技术中，身体技能可以以安全、重复的方式进行认知排练。此外，MP通过在精神上练习动作时激活相同的神经和肌肉结构来增加运动技能的学习和表现，就像在相同技能的物理练习中一样。试验数据表明，包括MP在内的康复计划可以提高运动性脊髓损伤患者的步速和腿部运动。本研究的目的是通过随机对照的方法，利用功能磁共振成像(F-MRI)验证踝关节背屈作为步行恢复的神经生物标志物在步行训练中的作用。这项多中心研究将在两个学术中心进行：辛辛那提大学的德雷克康复医院将作为主要研究中心，加州大学欧文分校将作为次要研究中心。这项完整的研究将总共32名运动不完全性脊髓损伤患者随机分为两组：(1)30分钟的MP训练结合运动训练；(2)仅常规运动训练。在每个研究地点，纳入16名脊髓损伤患者和8名健康受试者。受试者的随机比较将有助于确定包括MP在内的步态训练方案对因瘫痪而导致行走障碍的SCI患者的功能影响。步态分析模式和F MRI将测量结果变量，包括步态速度(主要结果)、步态运动学和主动自主腿部和脚踝运动。