MENTAL PRACTICE IMPACT ON GAIT AND CORTICAL ORGANIZATION IN SPINAL CORD INJURY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 尽管脊髓损伤（SCI）后的基本愿望是行走，但没有传统的康复方案可靠地显示出改善功能性Ambrosion。 心理练习（MP）是一种补充/替代医学（CAM）身心技术，其中物理技能可以以安全，重复的方式进行认知排练。 此外，MP通过激活相同的神经和肌肉结构来增加运动技能的学习和表现，当运动在心理上练习时，就像在身体上练习相同的技能一样。 试点数据表明，包括MP在内的康复计划可以增加运动不完全性SCI患者的步态速度和腿部运动。 本研究的目的是通过使用随机对照方法，使用功能性MRI（F MRI），显示MP参与在Ampendum训练中产生功能效应，并验证踝关节背屈作为Ampendum恢复的神经生物标志物。 本多中心研究将在2个学术中心进行：辛辛那提大学的Drake康复医院将作为主要研究中心，UC Irvine将作为次要研究中心。 完整的研究将总共32名运动不完全性SCI患者随机分为：（1）30分钟的MP课程结合运动训练;或（2）仅常规运动训练。 在每个研究中心，将入组16例SCI受试者和8例无SCI的健康受试者。 受试者的随机比较将有助于确定包括MP在内的步态训练方案对因瘫痪而导致上肢受损的SCI患者的功能影响。 步态分析模式和F MRI将测量结局变量，包括步态速度（主要结局）、步态运动学和主动随意腿部和踝关节运动。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite the fundamental desire to walk after spinal cord injury (SCI), no conventional rehabilitation regimen has reliably shown to improve functional ambulation. Mental practice (MP) is a complementary/alternative medicine (CAM) mind-body technique in which physical skills can be cognitively rehearsed in a safe, repetitive manner. Additionally, MP increases motor skill learning and performance by activating the same neural and muscular structures when movements are mentally practiced as during physical practice of the same skills. Pilot data suggests that a rehabilitation program including MP increases gait velocity and leg movement in people with motor incomplete SCI. The purpose of this study is to show that MP participation renders a functional effect in ambulation training and validate ankle dorsiflexion as a neural biomarker of ambulation recovery using functional MRI (F MRI) by using randomized controlled methods. This multi-center study will be conducted at 2 academic centers: Drake Rehabilitation Hospital at the University of Cincinnati will serve as the primary study center and UC Irvine will serve as the secondary study center. The complete study will randomize a total of 32 individuals with motor incomplete SCI to either: (1) 30-minute MP sessions combined with locomotor training; or (2) conventional locomotor training only. At each study site, 16 subjects with SCI and 8 healthy subjects without SCI will be enrolled. The randomized comparison of subjects will help determine the functional impact of a gait training regimen including MP in SCI patients with impaired ambulation due to paralysis. Gait analysis modalities and F MRI will measure the outcomes variables including gait velocity (primary outcome), gait kinematics, and active voluntary leg and ankle movement.