Arterial Properties from Stimulated Acoustical Emission
受激声发射的动脉特性
基本信息
- 批准号:8111987
- 负责人:
- 金额:$ 62.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-01-01 至 2013-06-30
- 项目状态:已结题
- 来源:
- 关键词:AccountingAcetylcholineAchievementAddressAnimal ModelAnimalsArteriesBehaviorBiopsyBlood PressureBlood VesselsCardiovascular systemCharacteristicsClinicClinicalClinical ResearchClinical TrialsCollaborationsCollagenColumbidaeComplexDataDependenceDevelopmentDiseaseDisease ProgressionElastinEndothelium-Dependent Relaxing FactorsEnrollmentEvaluationFamilyFamily suidaeFocused Ultrasound TherapyForearmFoundationsFrequenciesFundingGoalsHealthHistopathologyHourHumanHypertensionImageIn VitroIndividualInstitutionInvestigationKnowledgeLaboratoriesLaboratory ResearchLifeMagnetic Resonance ImagingMeasurableMeasurementMeasuresMechanicsMethodologyMethodsMinnesotaModelingModificationPharmaceutical PreparationsPhysiologic pulsePopulation StudyProbabilityPropertyProtocols documentationPulse PressureRadiationRegimenResearchResearch PersonnelResolutionScanningScienceSodiumSpeedStressSystemTechniquesTestingTimeTissuesTubeUltrasonographyUncertaintyUnited States National Academy of SciencesUnited States National Institutes of HealthUniversitiesValidationVasodilator Agentsarterial stiffnessbasebrachial arteryclinical applicationcohortcostdesignimaging modalityin vitro testingin vivoindexinginterestlaser velocimetrymathematical modelmembernovelpressureprogramsradial arteryresearch studyresponsetheoriestoolvibrationviscoelasticity
项目摘要
DESCRIPTION (provided by applicant): A simple and robust method to measure anisotropic arterial wall viscoelasticity would help with our understanding of disease progression. Also, it can assist with developing new drug regimens addressing new targets in the arterial wall. Estimation of the material properties of the arterial wall is a very complex problem because of the complexity of the wall itself. To approach this problem, we have designed a four-component program of investigation. The first part, described in Specific Aim 1, is designed to complete the mathematical and computational foundations that will support our newly developed methods of estimating anisotropic and viscoelastic material properties from measurable arterial wall responses to applied radiation force. This part of the investigation covers computation of the radiation stress from the ultrasound beams and two approaches to solving the inverse problem e.g., an analytic computational inverse method and an iterative FEM inverse method. The second part of the program, Aim 2, is designed to give laboratory based validation of the methods developed in Aim 1. The validation will be conducted on excised arteries and tubes. In addition, the dependence of the material properties on various constituents of the artery such as elastin and collagen will be determined. This Aim goes hand in hand with the third component, Aim 3, implementation of the developed methods in live pigs. The point is to test the methods in pig arteries that have a wide range of stiffness induced by disease, in this case, induced hypertension. Histomorphometry will be done on the arteries of the pigs and correlated with the measured viscoelastic moduli of the arterial walls. To begin the clinical application of these methods, in Aim 4, measurements will be made of the anisotropic viscoelastic moduli of arteries in humans that are already enrolled in ongoing clinical studies. Classical arterial stiffness measurements such as PWV and augmentation index, and pulse pressure, will be correlated to the viscoelastic arterial wall moduli measured with the new system. Implementation in a clinical scanner of the methods developed here will allow us to make measurements in humans using a portable scanner that can be added to NIH funded clinical trials with minimal modification of the ongoing protocols and minimal cost. Successful completion of these studies will result in knowledge of the relationship of the viscoelastic arterial wall moduli to an array of clinical attributes in the studied populations resulting in a valuable clinical ultrasound tool. PUBLIC HEALTH RELEVANCE: The long-term goal of this program is to noninvasively measure arterial wall material properties with high accuracy and precision using our novel vibrometry methods. The resulting quantitative measures will be amenable to clinical applications and population studies. The advantages of the methods proposed here are that they are noninvasive and fast allowing real-time measurement of arterial properties; they do not need estimates of transmural pressure; and they take into account the fact that properties are a function of frequency and direction within the arterial wall. Successful completion of this program will result in a new noninvasive scientific and clinical tool for measuring the viscoelastic frequency dependent anisotropic shear moduli of the vessel wall with higher temporal and spatial resolution than currently available.
描述(由申请人提供):测量各向异性动脉壁粘弹性的简单而稳健的方法将有助于我们了解疾病进展。此外,它可以帮助开发新的药物方案,解决动脉壁中的新目标。由于动脉壁本身的复杂性,动脉壁的材料性质的估计是一个非常复杂的问题。为了解决这个问题,我们设计了一个四个组成部分的调查方案。第一部分,在具体目标1中描述,旨在完成数学和计算基础,这将支持我们新开发的方法,估计各向异性和粘弹性材料的性能,从可测量的动脉壁响应所施加的辐射力。这部分的调查涵盖了计算的辐射应力从超声波束和两种方法来解决反问题,例如,解析计算反演法和迭代有限元反演法。该计划的第二部分,目标2,目的是给实验室为基础的验证目标1中开发的方法。将对切除的动脉和管路进行确认。此外,还将确定材料特性对动脉的各种成分(如弹性蛋白和胶原蛋白)的依赖性。这一目标与第三个组成部分,目标3,在生猪中实施开发的方法齐头并进。重点是在猪动脉中测试这些方法,这些动脉具有由疾病引起的广泛的硬度,在这种情况下,是诱发性高血压。将对猪的动脉进行组织形态测定,并与动脉壁的粘弹性模量测量值相关联。为了开始这些方法的临床应用,在目标4中,将对已经参加正在进行的临床研究的人体动脉的各向异性粘弹性模量进行测量。经典的动脉硬度测量,如PWV和增强指数,和脉压,将与粘弹性动脉壁模量测量的新系统。在临床扫描仪中实施本文开发的方法将使我们能够使用便携式扫描仪在人体中进行测量,该便携式扫描仪可以添加到NIH资助的临床试验中,对正在进行的方案进行最小的修改,并且成本最低。这些研究的成功完成将导致粘弹性动脉壁模量与研究人群中的一系列临床属性的关系的知识,从而产生有价值的临床超声工具。公共卫生关系:该计划的长期目标是使用我们的新型振动测量方法以高准确度和精度无创地测量动脉壁材料特性。由此产生的定量措施将适用于临床应用和人口研究。这里提出的方法的优点是,它们是无创的和快速的,允许实时测量动脉特性;它们不需要跨壁压的估计;并且它们考虑到特性是动脉壁内的频率和方向的函数的事实。该计划的成功完成将导致一个新的非侵入性的科学和临床工具,用于测量粘弹性频率依赖性各向异性剪切模量的血管壁具有更高的时间和空间分辨率比目前可用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
James Fowler Greenleaf其他文献
James Fowler Greenleaf的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('James Fowler Greenleaf', 18)}}的其他基金
Measuring arterial material properties using wave-based approaches with ultrasound and computational models - Administrative Supplement
使用基于波的超声方法和计算模型测量动脉材料特性 - 行政补充
- 批准号:
10268369 - 财政年份:2019
- 资助金额:
$ 62.95万 - 项目类别:
Measuring arterial material properties using wave-based approaches with ultrasound and computational models
使用基于波的超声方法和计算模型测量动脉材料特性
- 批准号:
10543720 - 财政年份:2019
- 资助金额:
$ 62.95万 - 项目类别:
Measuring arterial material properties using wave-based approaches with ultrasound and computational models
使用基于波的超声方法和计算模型测量动脉材料特性
- 批准号:
10356806 - 财政年份:2019
- 资助金额:
$ 62.95万 - 项目类别:
Measuring arterial material properties using wave-based approaches with ultrasound and computational models
使用基于波的超声方法和计算模型测量动脉材料特性
- 批准号:
10084311 - 财政年份:2019
- 资助金额:
$ 62.95万 - 项目类别:
ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
受激声发射的动脉特性
- 批准号:
6139300 - 财政年份:1999
- 资助金额:
$ 62.95万 - 项目类别:
ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
受激声发射的动脉特性
- 批准号:
6490620 - 财政年份:1999
- 资助金额:
$ 62.95万 - 项目类别:
Arterial Properties from Stimulated Acoustical Emission
受激声发射的动脉特性
- 批准号:
7010388 - 财政年份:1999
- 资助金额:
$ 62.95万 - 项目类别:
ARTERIAL PROPERTIES FROM STIMULATED ACOUSTICAL EMISSION
受激声发射的动脉特性
- 批准号:
6627473 - 财政年份:1999
- 资助金额:
$ 62.95万 - 项目类别:
Arterial Properties from Stimulated Acoustical Emission
受激声发射的动脉特性
- 批准号:
7725683 - 财政年份:1999
- 资助金额:
$ 62.95万 - 项目类别:
Arterial Properties from Stimulated Acoustical Emission
受激声发射的动脉特性
- 批准号:
7352727 - 财政年份:1999
- 资助金额:
$ 62.95万 - 项目类别:
相似海外基金
Spatiotemporal dynamics of acetylcholine activity in adaptive behaviors and response patterns
适应性行为和反应模式中乙酰胆碱活性的时空动态
- 批准号:
24K10485 - 财政年份:2024
- 资助金额:
$ 62.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Structural studies into human muscle nicotinic acetylcholine receptors
人体肌肉烟碱乙酰胆碱受体的结构研究
- 批准号:
MR/Y012623/1 - 财政年份:2024
- 资助金额:
$ 62.95万 - 项目类别:
Research Grant
CRCNS: Acetylcholine and state-dependent neural network reorganization
CRCNS:乙酰胆碱和状态依赖的神经网络重组
- 批准号:
10830050 - 财政年份:2023
- 资助金额:
$ 62.95万 - 项目类别:
Study on biological significance of acetylcholine and the content in food resources
乙酰胆碱的生物学意义及其在食物资源中的含量研究
- 批准号:
23K05090 - 财政年份:2023
- 资助金额:
$ 62.95万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
alpha7 nicotinic acetylcholine receptor allosteric modulation and native structure
α7烟碱乙酰胆碱受体变构调节和天然结构
- 批准号:
10678472 - 财政年份:2023
- 资助金额:
$ 62.95万 - 项目类别:
Diurnal Variation in Acetylcholine Modulation of Dopamine Dynamics Following Chronic Cocaine Intake
慢性可卡因摄入后乙酰胆碱对多巴胺动力学调节的昼夜变化
- 批准号:
10679573 - 财政年份:2023
- 资助金额:
$ 62.95万 - 项目类别:
Striatal Regulation of Cortical Acetylcholine Release
纹状体对皮质乙酰胆碱释放的调节
- 批准号:
10549320 - 财政年份:2022
- 资助金额:
$ 62.95万 - 项目类别:
Differential Nicotinic Acetylcholine Receptor Modulation of Striatal Dopamine Release as a Mechanism Underlying Individual Differences in Drug Acquisition Rates
纹状体多巴胺释放的烟碱乙酰胆碱受体差异调节是药物获取率个体差异的机制
- 批准号:
10553611 - 财政年份:2022
- 资助金额:
$ 62.95万 - 项目类别:
Mechanisms of nicotinic acetylcholine receptor modulation of cocaine reward
烟碱乙酰胆碱受体调节可卡因奖赏的机制
- 批准号:
10672207 - 财政年份:2022
- 资助金额:
$ 62.95万 - 项目类别:
Structural basis of nicotinic acetylcholine receptor gating and toxin inhibition
烟碱乙酰胆碱受体门控和毒素抑制的结构基础
- 批准号:
10848770 - 财政年份:2022
- 资助金额:
$ 62.95万 - 项目类别: