DISSECTING COX-1 RELATED GENE PATHWAYS IN OVARIAN CANCER

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 注：表和图与程序摘要一起上传。 试点项目  卵巢癌中考克斯-1相关基因通路的研究 卵巢癌是女性癌症死亡的第五大原因，在过去30年中生存率几乎没有变化。它通常是无症状的，直到肿瘤扩散到卵巢以外。环氧合酶-1（考克斯-1）是一种将花生四烯酸转化为前列腺素H2的酶，与考克斯-2相比，在卵巢癌中高度表达。本研究的目的是确定考克斯-1在卵巢癌发生中的具体作用。 假设和目的：本研究的长期目标是确定考克斯-1在卵巢癌发生中的具体作用。 我们假设考克斯-1表达调节磷脂酰肌醇3激酶/蛋白激酶B（PI 3 K/Akt）信号，参与卵巢肿瘤的生长和进展。我们通过比较考克斯-1阳性和考克斯-1阴性的卵巢癌细胞，探讨PI 3 K/Akt信号对EGF应答的分子机制。 重要性：如果我们确定考克斯-1确实是卵巢癌肿瘤进展的一个突出因素，这项研究可能为将来将其用作治疗这种致命疾病的生物标志物和靶点提供基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NOTE: Tables and Figures were uploaded with Program Summary. PILOT PROJECT  Dissecting COX-1 Related Gene Pathways in Ovarian Cancer Ovarian cancer is the fifth leading cause of cancer deaths among women with little change in survival rates over the past 30 years. It is typically asymptomatic until tumors have spread far beyond the ovaries. Cyclooxygenase-1 (COX-1), an enzyme that convert arachidonic acid to prostaglandin H2, is highly expressed in ovarian cancers, compared with COX-2. The goal of this research is to determine the specific contributions of COX-1 to ovarian carcinogenesis. Hypothesis and Aims: The long-range goal of this research is to determine the specific contributions of COX-1 to ovarian carcinogenesis. We hypothesize that COX-1 expression modulates phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signaling that is involved in ovarian tumor growth and progression. We explore molecular mechanisms of PI3K/Akt signaling in response to EGF comparing COX-1 positive cells to COX-1 negative ovarian cancer cells. Significance: If we determine that COX-1 is indeed a prominent factor in tumor progression in ovarian cancer, this research may provide the basis for its future use as a biomarker and target for therapy in the management of this deadly disease.