DISSECTING COX-1 RELATED GENE PATHWAYS IN OVARIAN CANCER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 注：表格和数字与计划摘要一起上传。 卵巢癌环氧合酶-1相关基因通路的初步研究 卵巢癌是女性癌症死亡的第五大原因，在过去30年中，存活率几乎没有变化。它通常是无症状的，直到肿瘤扩散到卵巢以外的地方。环氧合酶-1(COX-1)是一种将花生四烯酸转化为前列腺素H2的酶，与COX-2相比，在卵巢癌中高表达。本研究的目的是确定COX-1在卵巢癌发生中的特殊作用。 假设和目的：本研究的长期目标是确定COX-1在卵巢癌发生中的具体作用。我们推测，COX-1的表达调节磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)信号转导，参与卵巢肿瘤的生长和发展。我们比较了COX-1阳性和COX-1阴性的卵巢癌细胞，探讨了PI3K/Akt信号通路在EGF反应中的分子机制。 意义：如果我们确定COX-1确实是卵巢癌肿瘤进展中的一个重要因素，这项研究可能为未来将其用作生物标记物和治疗这一致命疾病的靶点提供基础。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. NOTE: Tables and Figures were uploaded with Program Summary. PILOT PROJECT  Dissecting COX-1 Related Gene Pathways in Ovarian Cancer Ovarian cancer is the fifth leading cause of cancer deaths among women with little change in survival rates over the past 30 years. It is typically asymptomatic until tumors have spread far beyond the ovaries. Cyclooxygenase-1 (COX-1), an enzyme that convert arachidonic acid to prostaglandin H2, is highly expressed in ovarian cancers, compared with COX-2. The goal of this research is to determine the specific contributions of COX-1 to ovarian carcinogenesis. Hypothesis and Aims: The long-range goal of this research is to determine the specific contributions of COX-1 to ovarian carcinogenesis. We hypothesize that COX-1 expression modulates phosphatidylinositol 3 kinase/protein kinase B (PI3K/Akt) signaling that is involved in ovarian tumor growth and progression. We explore molecular mechanisms of PI3K/Akt signaling in response to EGF comparing COX-1 positive cells to COX-1 negative ovarian cancer cells. Significance: If we determine that COX-1 is indeed a prominent factor in tumor progression in ovarian cancer, this research may provide the basis for its future use as a biomarker and target for therapy in the management of this deadly disease.