Distress Tolerance and Adolescent Smoking Cessation

痛苦耐受力和青少年戒烟

• 批准号: 7795104
• 负责人: Laura MacPherson
• 金额: $ 16.96万
• 依托单位: UNIV OF MARYLAND, COLLEGE PARK
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795104
• 关键词: Abstinence; Adolescent; Adult; Affect; Affective; Alcohol or Other Drugs use; Anxiety; Area; Attention; Basic Science; Behavior Therapy; Behavioral; Blood Pressure; Cigarette; Cognitive; Development; Development Plans; Distress; Educational Status; Effectiveness; Emotional; Emotions; Environment; Future; Galvanic Skin Response; Goals; Grant; Heart Rate; Individual Differences; Intervention; Investigation; K-Series Research Career Programs; Knowledge; Laboratories; Literature; Maryland; Measures; Mentors; Methods; Modeling; Moods; Morbidity - disease rate; Nicotine Dependence; Outcome; Participant; Patient Self-Report; Personality; Physiological; Procedures; Process; Psyche structure; Psychopathology; Reaction; Regulation; Relapse; Research; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Severities; Smoker; Smoking; Staging; Stress; Subgroup; Symptoms; Time; Tobacco; Tobacco use; Training; Treatment Protocols; Universities; Withdrawal; Withdrawal Symptom; Withholding Treatment; Youth; adolescent smoking; biobehavior; career development; college; depressive symptoms; distress tolerance; effective therapy; emotion regulation; experience; improved; innovation; interest; meetings; mortality; novel; patient oriented research; programs; psychologic; psychological stressor; psychosocial; response; skills; smoking cessation; smoking relapse; statistics; stressor; success; theories; therapy development; trait

DESCRIPTION (provided by applicant): Evidence suggests a significant percentage of adolescent daily smokers are interested in trying to quit smoking, frequently make attempts to quit, yet are unsuccessful in maintaining abstinence. Current models of relapse devote scant attention to mechanisms involved in adolescent smoking cessation despite widespread acceptance that adolescent daily smokers are more likely to be adult smokers. A promising new theory of early lapse from the adult smoking literature is distress tolerance. According to this theory, how one responds to discomfort is more important than severity of discomfort itself. Instead of focusing on severity of affective and physical symptoms occurring in the cessation process, examining factors surrounding how one reacts to these symptoms may be more promising. The objective of this proposal is to support the candidate's development of skills to perform patient-oriented research in the area of adolescent smoking cessation. The career development plan consists of obtaining training in biobehavioral and affective factors in adolescent smoking, relapse phenomena, and basic research. The University of Maryland College Park is an intellectually stimulating environment with superb resources for the candidate's successful achievement of her training goals. Dr. Carl Lejuez, the primary mentor, and Drs. Brown, Mermelstein, Dahl, and Strong (co mentors) are each experts in experimental psychopathology, smoking relapse, adolescent smoking, adolescent affect regulation, and statistics, respectively. The primary research aim is to examine the influence of pre-quit emotional and behavioral variables on lapse and relapse to smoking among 60 adolescent daily smokers undergoing a quit attempt. Participants will complete assessments of tobacco and other substance use, depressive symptoms, mood, anxiety sensitivity, personality, and nicotine dependence; and four laboratory challenge procedures: (a) mental arithmetic, (b) mirror tracing, (c) breath-holding, and (d) the cold pressortask. Beginning at baseline, quit day, and at days 7,14, 21, and 28, participants will be assessed for tobacco use, mood, and withdrawal symptoms. We will examine effects of behavioral reactivity to the challenge procedures on survival to first cigarette lapse and relapse. It is expected the results of this K23 project will increase basic knowledge about the role of vulnerability factors in adolescent smoking lapse and relapse, and will have direct implications for novel distress tolerance treatments for adolescent smoking.

描述（由申请人提供）：证据表明，有相当比例的青少年每日吸烟者有兴趣尝试戒烟，经常尝试戒烟，但未能成功保持戒烟。目前的复吸模型很少关注青少年戒烟的机制，尽管人们普遍认为青少年日常吸烟者更有可能是成年吸烟者。从成人吸烟文献中得出的一个很有前途的早期失效新理论是痛苦耐受。根据这一理论，一个人对不适的反应比不适本身的严重程度更重要。而不是专注于在戒烟过程中发生的情感和身体症状的严重程度，检查一个人如何对这些症状作出反应的因素可能更有希望。该提案的目的是支持候选人的技能发展，以在青少年戒烟领域进行以患者为导向的研究。职业发展计划包括获得青少年吸烟的生物行为和情感因素、复吸现象和基础研究方面的培训。马里兰州大学公园是一个智力刺激的环境，为候选人的成功实现她的培训目标的一流资源。主要导师卡尔·勒朱兹博士和布朗博士、梅尔斯坦博士、达尔博士和斯特朗博士（共同导师）分别是实验精神病理学、吸烟复发、青少年吸烟、青少年情感调节和统计学方面的专家。本研究的主要目的是探讨60名青少年每日吸烟者戒烟前的情绪和行为变量对戒烟失败和复吸的影响。参与者将完成烟草和其他物质使用、抑郁症状、情绪、焦虑敏感性、人格和尼古丁依赖的评估;以及四个实验室挑战程序：（a）心算，（B）镜像描记，（c）屏气，和（d）冷加压任务。从基线、戒烟日和第7、14、21和28天开始，将评估参与者的烟草使用、情绪和戒断症状。我们将研究对激发程序的行为反应对第一次戒烟和复吸的存活率的影响。预计这个K23项目的结果将增加对青少年吸烟失效和复发的脆弱性因素的作用的基本知识，并将对青少年吸烟的新型痛苦耐受治疗产生直接影响。