Family-Enhanced Cognitive Behavioral Therapy for Comorbid PTSD and Alcohol Abuse.

针对共病创伤后应激障碍（PTSD）和酗酒的家庭增强认知行为疗法。

• 批准号: 7877999
• 负责人: Meghan E. McDevitt-Murphy
• 金额: $ 15.14万
• 依托单位: UNIVERSITY OF MEMPHIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-05 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7877999
• 关键词: Abstinence; Address; Adherence; Affect; Afghanistan; Alcohol abuse; Alcohols; Award; Behavior Therapy; Behavioral; Burn injury; Clinical; Clinical Treatment; Clinical Trials; Cognitive; Cognitive Therapy; Communication; Comorbidity; Conduct Clinical Trials; Conflict (Psychology); Coping Skills; Data; Development; Diagnosis; Disease; Distress; Elements; Evaluation; Faculty; Family; Family member; Funding; Goals; Grant; Individual; Intervention; Intervention Studies; Iraq; Knowledge; Lead; Learning; Literature; Manuals; Manuscripts; Measures; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentorship; Methodology; Motivation; Participant; Patients; Pilot Projects; Population; Post-Traumatic Stress Disorders; Preparation; Psychological reinforcement; Randomized Clinical Trials; Relative (related person); Research; Research Personnel; Research Project Grants; Research Training; Risk; Sampling; Scientist; Social support; Spouses; Substance abuse problem; Surveys; Symptoms; Testing; Training; Treatment Efficacy; Universities; Veterans; Vietnam; Walkers; War; Writing; alcohol abstinence; alcohol abuse therapy; alcohol use disorder; base; career; combat; compliance behavior; design; experience; high risk; improved; innovation; meetings; member; programs; psychoeducation; psychosocial; randomized trial; responsible research conduct; skills; skills training; substance abuser; trial comparing

DESCRIPTION (provided by applicant): The overall goal of this Mentored, Patient-Oriented Research Career Development Award (K23) proposal is to enable Dr. McDevitt-Murphy to develop her career as a clinical scientist with a program of research in the development and evaluation of psychosocial interventions for co-occurring alcohol use disorders (AUD) and posttraumatic stress disorder (PTSD). Specifically, she will focus on AUD-PTSD among veterans recently returned from deployments to overseas conflicts, a population at high risk for AUD-PTSD. Returning veterans with AUD-PTSD would likely benefit from a cognitive-behavioral skills-based treatment focused on both PTSD symptoms and alcohol abuse, with involvement by significant others/family members. To accomplish the goal of becoming an independent researcher pursuing this line of research, the candidate would use the 5-year K23 award to pursue a training plan and to conduct a pilot study with mentorship from experts in the field. The training plan is designed to meet the following objectives: 1) Develop expertise in the design and conduct of clinical trials, particularly as they relate to psychosocial interventions research; 2) Develop expertise in research on AUD treatment; 3) Develop expertise in research on interventions involving family or significant others; 4) Enhance knowledge and skills related to PTSD research; 5) Improve understanding of methodology and statistical analyses relevant to clinical trials; 6) Acquire further training in the responsible conduct of research; 7) Improve grant writing and manuscript preparation skills. Dr. McDevitt-Murphy will also conduct a 5-year research project designed to develop and pilot test a cognitive-behavioral skills based intervention for comorbid AUD-PTSD that includes involvement by family members/ significant others. During the first 24 months of the award, Dr. McDevitt-Murphy will develop the manual and test it in an open trial of 15 patients. Subsequently, Dr. McDevitt-Murphy will conduct a small, randomized trial comparing the experimental treatment to an individual coping skills treatment for AUD. These data will be collected to estimate an effect size so that a larger trial may be planned. Dr. McDevitt-Murphy will submit an R01 application in year 4 of this award to obtain funding for a full-scale clinical trial. The training and research plans will be carried out under the mentorship of Drs. M. Trade Shea, Peter M. Monti, Ivan W. Miller, and Caron Zlotnick, all faculty members at Brown University.

描述（由申请人提供）：这个指导，以患者为导向的研究职业发展奖（K23）提案的总体目标是使McDevitt-Murphy博士能够发展她作为临床科学家的职业生涯，并开展一项研究计划，开发和评估同时发生的酒精使用障碍（AUD）和创伤后应激障碍（PTSD）的心理社会干预措施。具体来说，她将专注于最近从海外冲突中返回的退伍军人中的AUD-PTSD，这是一个AUD-PTSD高风险人群。患有AUD-PTSD的退伍军人可能会受益于以认知行为技能为基础的治疗，重点是PTSD症状和酒精滥用，并由重要的其他人/家庭成员参与。为了实现成为一名独立研究人员从事这一研究的目标，候选人将使用5年的K23奖来实施培训计划，并在该领域专家的指导下进行试点研究。 培训计划旨在实现以下目标：1）发展临床试验设计和实施方面的专业知识，特别是与心理社会干预研究相关的专业知识; 2）发展AUD治疗研究方面的专业知识; 3）发展涉及家庭或重要他人干预研究方面的专业知识; 4）增强与PTSD研究相关的知识和技能; 5）提高对临床试验相关方法和统计分析的理解; 6）获得负责任的研究行为的进一步培训; 7）提高赠款写作和手稿准备技能。McDevitt-Murphy博士还将进行一项为期5年的研究项目，旨在开发和试点测试一种基于认知行为技能的干预措施，用于合并AUD-PTSD，其中包括家庭成员/重要他人的参与。在该奖项的前24个月，McDevitt-Murphy博士将开发该手册，并在15名患者的开放试验中进行测试。随后，McDevitt-Murphy博士将进行一项小型随机试验，将实验性治疗与AUD的个体应对技能治疗进行比较。将收集这些数据以估计效应量，以便计划更大规模的试验。McDevitt-Murphy博士将在该奖项的第4年提交R 01申请，以获得全面临床试验的资金。培训和研究计划将在M博士的指导下进行。作者：Peter M.伊万·蒙蒂米勒和卡隆·兹洛尼克，都是布朗大学的教员。