Development of a Miniature Plasma Brush for Dental Clinical Applications

项目描述（由申请人提供）：本项目主要目的是开发一种用于牙科临床应用的微型大气冷等离子体刷（m- ACPB）。本项目的创新点是利用近年来发展的新型非热大气等离子体技术进行牙科治疗，防止蛀牙，提高牙科复合修复体的耐久性和寿命。非热大气等离子体是一种具有化学反应性的气体介质，具有穿透不规则空洞和裂缝并杀死细菌的能力。此外，等离子体可以在液体中扩散几毫米。这一特点使得非热等离子体非常适合在潮湿的口腔环境中治疗、清洁、消毒蛀牙和氟化牙釉质。等离子体治疗蛀牙或牙表面使我们能够避免污染，积极对抗细菌感染，有效地氟化牙齿表面，为蛀牙提供额外的清洁，并准备/设计牙齿表面，通过简单的等离子体处理过程与粘合剂和密封剂材料牢固耐用地结合。这种牙科临床应用将通过开发适合牙科临床使用的m-ACPB来实现。

DESCRIPTION (provided by applicant): The main objective of this project is to develop a miniature atmospheric cold plasma brush (m- ACPB) for dental clinical applications. The innovation of this project is the utilization of the recently developed novel non-thermal atmospheric plasma technology for dental treatment to prevent tooth decay and improve the durability and longevity of dental composite restoration. Non-thermal atmospheric plasma is a gaseous medium that is chemically reactive and has the capability to penetrate irregular cavities and fissures and kill bacteria. Furthermore, plasma species can spread up to a few millimeters into a fluid. This feature make non-thermal plasmas extremely suitable to treat, clean, disinfect tooth decay, and fluorinate enamel in a wet oral environment. Plasma treatment of tooth decays or dental surfaces allows us to avoid contamination, actively fight bacterial infections, effectively fluorinate the tooth surfaces, offer additional cleaning to the decayed matters, and prepare/engineer the dental surface for strong and durable bonding to adhesive and sealant materials with a simple plasma treatment process. Such dental clinical applications will be achieved through the development of an m-ACPB that is suitable for dental clinical use. PUBLIC HEALTH RELEVANCE: Nanova, Inc. is developing a miniature atmospheric cold plasma brush (m-ACPB) for dental clinical applications. The innovation of this project is the utilization of the recently developed novel non-thermal atmospheric plasma technology for dental treatment to prevent tooth decay and improve the durability and longevity of dental composite restoration, and could become a high-impact innovation in dentistry.