"3D Camera Ring" - Novel Automated 360-degree Surface Profiling System for Small

描述（由申请人提供）：先进的断层光学成像的影响可能是巨大的，因为它提供了一个工作框架，而特定的功能或分子事件可以在深层组织中定量成像，因此显着推进基础癌症研究，药物发现和医疗保健实践。先进的漫射光学层析成像（DOT）算法需要良好的先验知识的边界几何形状的漫射介质被成像，以提供准确的前向模型的光在该介质中的传播。迄今为止，还没有已知的技术用于自动提取具有准确和实时体内性能的完整3600 3D边界。为了满足小动物成像社区的这一迫切需求，Technest Inc.与布里格姆妇女医院（BWH）、哈佛医学院（HMS）和塔夫茨大学合作，提出使用新颖3D摄像机环系统用于小动物DOT成像。代替使用单个相机和运动台来获取动物体表的多个图像，相机环可以在体内同时获取多个（16个）表面图像并自动生成动物的3D表面模型。3D模型为DOT子系统提供准确的几何边界信息。我们提出的成像系统的显着优势包括：“自动完成3600小动物（小鼠）体表覆盖;”高速和体内成像能力;“最小的后处理;”相干集成的三维表面数据与多光谱DOT成像模式;“紧凑和低成本的设计。公共卫生相关性：申报的3600 3D Camera Ring增强型DOT系统代表了一种新的成像模式，对非侵入性光学成像领域的临床前分子成像具有直接影响。这项研究的影响可能是巨大的，因为它提供了一个工作框架，而特定的功能或分子事件可以定量成像，从而显着推进基础癌症研究，药物发现和医疗保健实践。

DESCRIPTION (provided by applicant): The impact of advancing tomographic optical imaging is potentially enormous since it offers a work frame whereas specific functional or molecular events could be quantitatively imaged in deep tissues and hence significantly advances basic cancer research, drug discovery and healthcare practices. Advanced diffuse optical tomography (DOT) algorithms require good a priori knowledge of the boundary geometry of the diffuse medium being imaged to provide accurate forward models of light propagation within this medium. To date, there is no known technique for automated extracting complete 3600 3D boundaries with accurate and real-time in vivo performance. To address this pressing need in the small animal imaging community, Technest Inc. in collaboration with Brigham and Women's Hospital (BWH), Harvard Medical School (HMS), and Tufts University propose to use a novel 3D camera ring system for small animal DOT imaging. Instead of using a single camera and a motion stage to acquire multiple images of the animal body surface, the camera ring can simultaneously acquire multiple (16) surface images in vivo and automatically generate 3D surface model of the animal. The 3D model provides accurate geometric boundary information for the DOT subsystem. The distinguished advantages of our proposed imaging system include: " Automated complete 3600 coverage of small animal (mouse) body surface; " High speed and In vivo imaging capability; " Minimal post processing; " Coherent integration of 3D surface data with multi-spectral DOT imaging modality; " Compact and low-cost design. PUBLIC HEALTH RELEVANCE: The proposed 3600 3D Camera Ring enhanced DOT system represents a new image modality that has a direct impact on preclinical molecular imaging in the area of non-invasive optical imaging. The impact of this research is potentially enormous since it offers a work frame whereas specific functional or molecular events could be quantitatively imaged and hence significantly advances basic cancer research, drug discovery and healthcare practices.