"3D Camera Ring" - Novel Automated 360-degree Surface Profiling System for Small

“3D相机环”——新型小型自动化360度表面分析系统

• 批准号: 8141150
• 负责人: GONGJIE YIN
• 金额: $ 34.37万
• 依托单位: TECHNEST, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-16 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141150
• 关键词: Address; Adverse effects; Algorithms; Animal Model; Animal Structures; Animals; Area; Basic Cancer Research; Body Surface; Calibration; Cardiopulmonary; Cardiovascular Diseases; Collaborations; Communities; Computer software; Data; Diffuse; Disease; Effectiveness; Event; Fiber; Functional Imaging; Health; Healthcare; Hospitals; Image; Imaging Techniques; Inflammation; Investigation; Knowledge; Lasers; Life; Light; Lighting; Measurement; Measures; Methods; Modeling; Molecular; Monitor; Motion; Mus; Neoplasm Metastasis; Optical Tomography; Output; Pathway interactions; Pattern; Performance; Phase; Process; Research; Resolution; Rheumatoid Arthritis; Small Animal Imaging Systems; Small Business Innovation Research Grant; Source; Speed; Staging; Stroke; Structure; Surface; Survival Rate; System; Techniques; Three-Dimensional Image; Three-Dimensional Imaging; Time; Tissues; Treatment Efficacy; Universities; Woman; Work; anticancer research; cost; design; diffuse optical tomography; drug discovery; graphical user interface; imaging modality; improved; in vivo; medical schools; meetings; molecular imaging; novel; optical imaging; pre-clinical; prototype; reconstruction; research clinical testing; research study; sensor; software systems; three-dimensional modeling; tumor; user-friendly

DESCRIPTION (provided by applicant): The impact of advancing tomographic optical imaging is potentially enormous since it offers a work frame whereas specific functional or molecular events could be quantitatively imaged in deep tissues and hence significantly advances basic cancer research, drug discovery and healthcare practices. Advanced diffuse optical tomography (DOT) algorithms require good a priori knowledge of the boundary geometry of the diffuse medium being imaged to provide accurate forward models of light propagation within this medium. To date, there is no known technique for automated extracting complete 3600 3D boundaries with accurate and real-time in vivo performance. To address this pressing need in the small animal imaging community, Technest Inc. in collaboration with Brigham and Women's Hospital (BWH), Harvard Medical School (HMS), and Tufts University propose to use a novel 3D camera ring system for small animal DOT imaging. Instead of using a single camera and a motion stage to acquire multiple images of the animal body surface, the camera ring can simultaneously acquire multiple (16) surface images in vivo and automatically generate 3D surface model of the animal. The 3D model provides accurate geometric boundary information for the DOT subsystem. The distinguished advantages of our proposed imaging system include: " Automated complete 3600 coverage of small animal (mouse) body surface; " High speed and In vivo imaging capability; " Minimal post processing; " Coherent integration of 3D surface data with multi-spectral DOT imaging modality; " Compact and low-cost design. PUBLIC HEALTH RELEVANCE: The proposed 3600 3D Camera Ring enhanced DOT system represents a new image modality that has a direct impact on preclinical molecular imaging in the area of non-invasive optical imaging. The impact of this research is potentially enormous since it offers a work frame whereas specific functional or molecular events could be quantitatively imaged and hence significantly advances basic cancer research, drug discovery and healthcare practices.

描述(申请人提供)：先进的断层成像光学成像的影响可能是巨大的，因为它提供了一个工作框架，而特定的功能或分子事件可以在深层组织中定量成像，从而显著促进基础癌症研究、药物发现和医疗实践。先进的漫反射光学层析成像(DOT)算法需要对被成像的漫射介质的边界几何有良好的先验知识，以提供该介质内光传播的准确正演模型。到目前为止，还没有已知的技术来自动提取完整的3600个3D边界，并具有准确和实时的活体性能。为了满足小动物成像领域的这一迫切需求，Technest Inc.与布里格姆妇女医院(BWH)、哈佛医学院(HMS)和塔夫茨大学合作，提议使用一种新颖的3D相机环系统来进行小动物DOT成像。该摄像环可以同时采集活体内的多(16)幅表面图像，自动生成动物的3D表面模型，而不是使用单个摄像头和运动平台来获取动物身体表面的多幅图像。3D模型为DOT子系统提供了准确的几何边界信息。我们建议的成像系统的显著优势包括：“自动完成小动物(老鼠)体表的3600覆盖；”高速和活体成像能力；“最少的后处理；”3D表面数据与多光谱DOT成像模式的相干集成；“紧凑和低成本的设计”。公共卫生相关性：拟议的3600 3D照相机环增强DOT系统代表了一种新的成像方式，直接影响了非侵入性光学成像领域的临床前分子成像。这项研究的影响可能是巨大的，因为它提供了一个工作框架，而特定的功能或分子事件可以被定量地成像，从而显著促进基础癌症研究、药物发现和医疗实践。