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COOPERATIVE AGREEGMENT TO THE MEDI RESEARC COUNCIL (MRC) OF SOUTH AFRICA FOR TB

与南非医学研究委员会 (MRC) 签署的结核病合作协议

基本信息

批准号：
8114189
负责人：
ANTHONY DAVID MBEWU
金额：
--
依托单位：
MEDICAL RESEARCH COUNCIL OF SOUTH AFRICA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-07-01 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8114189
关键词：
COOPERATIVE AGREEGMENT MEDI RESEARC COUNCIL

项目摘要

DESCRIPTION (provided by applicant): Tuberculosis (TB) remains one of the world's biggest killers, despite the availability of effective drugs and disease control strategies. Although epidemiological trends seem to be stabilizing in most regions of the world, Africa remains the exception with 20% annual growth in TB cases reported, largely due to concurrent HIV epidemics. South Africa ranks 2nd in the world in terms of TB incidence (number of cases per capita) and 7th in terms of TB burden (total number of cases). More than 60% of TB patients in SA are co-infected with HIV. The TB epidemic is compounded by the emergence of multidrug-resistant TB (MDR-TB) in all provinces. MDR-TB is difficult to treat and extremely expensive (up to 100 times the cost of drug-susceptible TB), and associated with HIV can result in uncontrollable epidemics with devastating economic and social consequences. Challenges posed by the goal of TB control are increasing in South Africa, largely as a result of the HIV co-epidemic and increases in TB drug resistance, now compounded by the emergence of extensively drug-resistant TB (XDR-TB) in association with HIV. Gains made in HIV/AIDS care and treatment in South Africa stand to be lost through the threat of drug-resistant TB, requiring a concerted national effort to avoid the epidemic of drug-susceptible TB being replaced by an epidemic of virtually unbeatable TB. This activity highlights the MRC's comparative advantage in addressing the key challenges of HIV associated TB and drug-resistant TB in the South African context. The MRC is acknowledged worldwide for its expertise in MDR-TB management and laboratory capability and has recently emerged as a focal point for XDR-TB expertise and management capacity development. Seed funding is required to enable MRC to coordinate/facilitate a national response to XDR-TB in SA and in the Southern Africa Development Community (SADC) region, to assist SA provinces and SADC countries in strategic planning and policy formulation, and to facilitate rapid translation of operational and programmatically relevant research results into improved policies and practices. Dissemination of validated data on drug-resistant TB as well as standardized public health information is another key need. Aim and Objectives To assist National and Provincial Departments of Health in SA in developing an appropriate response to the challenges of M(X)DR-TB and HIV; To provide technical assistance and national coordination to accomplish the MDR-TB goals of the Stop-TB Global Plan; To assist with capacity strengthening of health services and laboratory infrastructure in Southern Africa in order to allow sound diagnosis and treatment of M(X)DR-TB patients.

描述（由申请人提供）：尽管有有效的药物和疾病控制策略，结核病仍然是世界上最大的杀手之一。尽管流行病学趋势似乎在大多数区域趋于稳定

项目成果

期刊论文数量（12）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review.

DOI：
10.1186/1471-2458-9-450
发表时间：
2009-12-05
期刊：
BMC public health
影响因子：
4.5
作者：
Rehm J;Samokhvalov AV;Neuman MG;Room R;Parry C;Lönnroth K;Patra J;Poznyak V;Popova S
通讯作者：
Popova S

Impact of community tracer teams on treatment outcomes among tuberculosis patients in South Africa.

DOI：
10.1186/1471-2458-12-621
发表时间：
2012-08-07
期刊：
BMC public health
影响因子：
4.5
作者：
Bronner LE;Podewils LJ;Peters A;Somnath P;Nshuti L;van der Walt M;Mametja LD
通讯作者：
Mametja LD

Assessing the utility of Xpert(®) MTB/RIF as a screening tool for patients admitted to medical wards in South Africa.