Development, Evaluation, and Testing of the Sesame LIMS

描述（由申请人提供）：Sesame是一个多功能的基于web的实验室信息管理系统，由威斯康星大学麦迪逊分校开发，在世界各地的多个实验室中用于小规模和大规模应用。Sesame支持收集、组织、处理和分析来自各种来源的信息，包括数据库、工作台科学家、实验室仪器和软件包。Sesame在结构和功能蛋白质组学研究、核磁共振谱资源和分子相互作用设施等共享仪器中心的管理方面证明了其价值。Sesame系统使合作者能够参与研究项目，具有同等的信息访问权限，并且能够输入结果和处理数据，而不考虑位置（给定Web访问权限）。Sesame软件是用Java编写的，使用CORBA作为中间件，并与关系数据库管理系统接口。所请求的资金将用于支持Sesame软件包的持续开发、评估和测试。软件开发将旨在(1)提高Sesame框架的效率和灵活性，(2)使用户更容易根据自己的需要定制软件，(3)改进现有应用程序，以及(4)开发其他应用程序。目标是使软件能够提供给结构生物学家、分子生物学家和生物化学家等更大的客户。作为这项工作的一部分，我们将为开发人员创建通用对象，以便他们可以开发Sesame模块来解决特定于他们实验室的问题。我们将确保软件运行在各种平台上，支持各种关系数据库管理系统，并且对防火墙友好。我们将改进软件的文档，继续开发可网络访问的用户帮助页面，并为更广泛的实验室仪器创建Sesame接口。为各种Sesame应用程序开发的模式和受控词汇表将在web上提供给感兴趣的用户。所有的软件都将是开源的。我们将扩展用于从外部数据存储库导入数据和向外部数据存储库导出数据的协议。我们提出了进度评估的里程碑。

DESCRIPTION (provided by applicant): Sesame is a versatile Web-based laboratory information management system developed at the University of Wisconsin-Madison that is in use in multiple laboratories around the world both for small-scale and large- scale applications. Sesame supports the gathering, organization, processing, and analysis of information from a variety of sources, including databases, bench scientists, laboratory instrumentation, and software packages. Sesame has proved its value in structural and functional proteomics investigations, in the management of shared instrumentation centers such as NMR spectroscopy resources and molecular interaction facilities. The Sesame system enables collaborators to participate in a research project, with equivalent access to information and the ability to enter results and process data irrespective of location (given Web access). The Sesame software is written in Java, uses CORBA as a middleware and is interfaced to a relational database management system. The requested funds will be used to support the continued development, evaluation, and testing of the Sesame software package. The software development will be aimed at (1) improving the efficiency and flexibility of the Sesame framework, (2) making it easier for users to customize the software for their own needs, (3) improving existing applications, and (4) developing additional applications. The goals are to make the software available to a larger clientele of structural biologists, molecular biologists, and biochemists. As part of this effort, we will create universal objects for developers so that they can develop Sesame modules to solve problems specific to their laboratory. We will ensure that the software runs on a variety of platforms, supports a variety of relational database management systems, and is firewall friendly. We will improve the documentation of the software, continue development of web-accessible user help pages, and create Sesame interfaces to a wider range of laboratory instrumentation. The schema and controlled vocabularies developed for various Sesame applications will be made available on the web to interested users. All software will be open-source. We will extend protocols for importing data from and exporting data to external data repositories. We present milestones for progress assessment.