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Hedgehog signaling in adult bone and cartilage homeostasis

Hedgehog signaling in adult bone and cartilage homeostasis
成人骨和软骨稳态中的刺猬信号传导
批准号:
8149450
负责人:
Yingzi Yang
金额:
$37.65万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
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英文摘要
Hedgehog (Hh) signaling is required for the differentiation of mesenchymal progenitors into osteoblasts during endochondral bone formation. However, the role of Hh signaling in differentiated osteoblasts during adult bone homeostasis remains to be elucidated. In addition, Hh signaling is also required to control chondrocyte proliferation and hypertrophy. In the past year we found that in the postnatal bone, Hh signaling activity has to be tightly regulated. Abnormal activation of Hh signaling in the bone leads to tumor-like lesions.
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会议论文
Cellular and molecular mechanism of Hippo signaling in suppressing liver tumor formation
  • 批准号:
    10216195
  • 项目类别:
  • 资助金额:
    $38.77万
  • 财政年份:
    2018
  • 负责人:
    Yingzi Yang
  • 依托单位:
Cellular and molecular mechanism of Hippo signaling in suppressing liver tumor formation
  • 批准号:
    10449975
  • 项目类别:
  • 资助金额:
    $38.0万
  • 财政年份:
    2018
  • 负责人:
    Yingzi Yang
  • 依托单位:
Cellular and molecular mechanism of Hippo signaling in suppressing liver tumor formation
  • 批准号:
    9978754
  • 项目类别:
  • 资助金额:
    $38.77万
  • 财政年份:
    2018
  • 负责人:
    Yingzi Yang
  • 依托单位:
Mechanisms of Hippo signaling in Alcoholic liver disease
  • 批准号:
    9296288
  • 项目类别:
  • 资助金额:
    $24.37万
  • 财政年份:
    2017
  • 负责人:
    Yingzi Yang
  • 依托单位:
海外基金