Request for Purchase of High-Performance MRI System for in-vivo Rodent Imaging

请求购买用于啮齿类动物体内成像的高性能 MRI 系统

• 批准号: 8948335
• 负责人: Anthony J. BAKER
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2015-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8948335
• 关键词: Address; Anatomy; Animal Experimentation; Animals; Area; Biomedical Research; Blood Vessels; Body Composition; Brain; Brain Injuries; Cardiac; Cardiovascular system; Coiled Bodies; Core Facility; Disease; Dourine; Electronics; Equipment; Fatty acid glycerol esters; Functional Imaging; Funding; Head; Health; Heart; Heart Diseases; Housing; Image; Injury; Institution; Investigation; Ischemia; Joints; Kidney; Kidney Failure; Laboratories; Life; Location; Magnetic Resonance Imaging; Magnetism; Maintenance; Malignant Neoplasms; Measurement; Measures; Minor; Modeling; Monitor; Mus; Musculoskeletal; Myocardium; Nephrology; Nerve; Nervous System Neoplasms; Neurosciences; Organ; Orthopedics; Performance; Physiological; Price; Protocols documentation; Rattus; Request for Proposals; Research; Research Personnel; Research Project Grants; Resolution; Resources; Rodent; Safety; San Francisco; Shapes; Structure; System; Temperature; Tendon structure; Tissues; Vendor; Ventricular; Veterans; Water; Work; body system; bone; cohort; cost; discount; heart motion; imaging system; in vivo; in vivo imaging; innovation; instrument; muscle form; musculoskeletal injury; patient population; programs; public health relevance; skeletal injury; tumor

 DESCRIPTION (provided by applicant): This proposal requests funding for a Compact, High-Performance Magnetic Resonance Imaging (MRI) System for in-vivo Rodent Imaging. Rodents are the most commonly used experimental animals in biomedical research. However, the VA San Francisco does not have rodent MRI imaging capability. Currently, projects that need to monitor internal structures and physiological functions within living rats or mice are hampered by the lack of a high-resolution rodent MRI system. Therefore, acquisition of a rodent MRI system will fulfill a critical need for multiple research projects at the VA SF. Eight major users and four minor users compose the first cohort of investigators who have expressed a critical need for this instrument. These investigators perform research in diverse research areas of Cancer, Cardiovascular, Musculoskeletal, Nephrology and Neuroscience. A high performance rodent MRI system will make possible precise measurements of multiple in- vivo parameters. For example, monitoring of: * Tumor location, mass, and shape * Ischemic regions in mouse brain and nerves * Cardiac structure, ventricular volumes and contractile function of all 4 chambers of the heart and the presence of ischemic injury * Skeletal muscle mass and ischemic injury * Integrity of joints, tendons and bone. Vascular imaging. * Kidney structure and damage Therefore, a rodent MRI system will aid the research of multiple projects in several areas of investigation that are critically relevan to veteran's health. These projects involve exploration of new therapies to treat brain injury, cancer, heart disease, musculoskeletal injury, orthopedic diseases, and renal failure. These diseases are highly relevant to the veteran patient population. The instrument requested is a Bruker ICON MRI system. This is a relatively low priced MRI system that has two innovative and significant technical advantages: First, the Bruker ICON MRI system uses a compact permanent magnet rather than a traditional superconducting MRI magnet. Therefore, the permanent magnet does not require cooling with cryogens. Accordingly, the significant costs and maintenance associated with a traditional superconducting magnet are not required. This system has no ongoing maintenance requirements. It does not contain parts that need regular replacement or replenishing. Second, the Bruker ICON MRI system uses a self-shielded permanent magnet, and therefore does not require additional external shielding. The magnet has negligible magnetic fringe fields outside of the magnet. Thus, the compact magnet can be housed in regular laboratory space and does not require a separate shielded location. Furthermore, the Bruker ICON system does not require MRI safety protocols that must be used with a traditional MRI system. In summary, acquisition of a rodent MRI system will address a significant research need, and will greatly aid many research projects in multiple fields covering diseases that are highly significant to the veteran patient population.

 描述（由申请人提供）： 该提案要求为用于体内啮齿动物成像的紧凑型高性能磁共振成像（MRI）系统提供资金。啮齿动物是生物医学研究中最常用的实验动物。然而，退伍军人管理局旧金山分部不具备啮齿动物MRI成像能力，弗朗西斯科。目前，需要监测活体大鼠或小鼠内部结构和生理功能的项目因缺乏高分辨率啮齿动物MRI系统而受到阻碍。因此，收购啮齿动物MRI系统将满足VA SF多个研究项目的关键需求。八个主要用户和四个次要用户组成的第一批研究者谁表示迫切需要这个工具。这些研究人员在癌症，心血管，肌肉骨骼，肾脏和神经科学的不同研究领域进行研究。高性能的啮齿动物MRI系统将使多个体内参数的精确测量成为可能。例如，监测：* 肿瘤位置、质量和形状 * 小鼠脑和神经中的缺血区域 * 心脏结构、心室容积和心脏所有4个腔室的收缩功能以及缺血性损伤的存在 * 骨骼肌质量和缺血性损伤 * 关节、肌腱和骨骼的完整性。血管成像。 * 肾脏结构和损伤因此，啮齿动物MRI系统将有助于在与退伍军人健康密切相关的几个调查领域进行多个项目的研究。这些项目涉及探索治疗脑损伤、癌症、心脏病、肌肉骨骼损伤、骨科疾病和肾衰竭的新疗法。这些疾病与退伍军人患者人群高度相关。申请的仪器为Bruker ICON MRI系统。这是一款价格相对较低的MRI系统，具有两个创新和显著的技术优势：首先，布鲁克ICON MRI系统使用紧凑型永磁体，而不是传统的超导MRI磁体。因此，永磁体不需要用冷冻剂冷却。因此，不需要与传统超导磁体相关联的显著成本和维护。该系统没有持续维护要求。它不包含需要定期更换或补充的部件。其次，布鲁克ICON MRI系统使用自屏蔽永磁体，因此不需要额外的外部屏蔽。磁体外部的边缘磁场可忽略不计。因此，紧凑型磁体可以容纳在常规的实验室空间中，并且不需要单独的屏蔽位置。此外，布鲁克ICON系统不需要传统MRI系统必须使用的MRI安全协议。总之，收购啮齿动物MRI系统将满足重大研究需求，并将极大地帮助多个领域的许多研究项目，涵盖对退伍军人患者群体非常重要的疾病。