Barriers in Translating Genomic Research into State Public Health Programs

将基因组研究转化为国家公共卫生计划的障碍

• 批准号: 8869018
• 负责人: Laura Senier
• 金额: $ 17.72万
• 依托单位: NORTHEASTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-23 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8869018
• 关键词: Address; Administrator; Adult; Attention; Attitude; Bioethics; Biotechnology; Career Choice; Caring; Case Study; Chicago; Child Care; Chronic Disease; Clinical Services; Collaborations; Communities; Congenital Abnormality; Connecticut; Consensus; Data; Development; Diffusion; Diffusion of Innovation; Dimensions; Doctor of Philosophy; Economics; Education and Outreach; Effectiveness; Elements; Empirical Research; Ensure; Ethical Issues; Ethics; Evaluation; Evaluation Research; Face; Genes; Genetic; Genetic Markers; Genetic Programming; Genetic Services; Genomics; Goals; Guidelines; Health; Health Personnel; Health Policy; Health Sciences; Healthcare; Hereditary Disease; Human Genome Project; Individual; Institutes; Interview; Investments; Knowledge; Laws; Lead; Leadership; Legal; Life Cycle Stages; Maternal and Child Health; Medicine; Mentored Research Scientist Development Award; Mentors; Mentorship; Michigan; Mission; Modeling; Modernization; National Human Genome Research Institute; Neonatal Screening; New York; Onset of illness; Outcome; Patients; Policies; Policy Analysis; Politics; Population; Population Genetics; Population Surveillance; Program Development; Program Evaluation; Public Health; Public Policy; Qualifying; Qualitative Methods; Recruitment Activity; Registries; Research; Research Activity; Research Design; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Resources; Sampling; Science; Science Policy; Services; Sociology; Solutions; Stigmatization; Strategic Planning; Structure; Study Section; Suggestion; System; Theoretical model; Time; Training; Training Activity; Translating; Translational Research; Universities; Utah; Variant; Wisconsin; Work; base; burden of illness; career; comparative; cost; cost effective; design; evidence base; expectation; genetic technology; improved; innovation; medical specialties; medically underserved; meetings; multidisciplinary; organizational structure; population health; professor; programs; public education; response; social; sound

DESCRIPTION (provided by applicant): This revised application for a Mentored Research Scientist Development Award (K01) is designed to support the career of Laura Senier, MPH, PhD, an assistant professor at the University of Wisconsin-Madison. Dr. Senier's goals are (1) to obtain additional training in population genetics, public policy analysis, and ethical frameworks governing emerging genetic technologies; (2) to build a research program that explores technical, political, and ethical barriers in translating genetic discoveries to public health poliies and programs; and (3) to become an independent investigator in the politics of research translation. Dr. Senier will accomplish these goals through a combination of formal coursework, mentored collaboration, and empirical research on state public health policy. The research plan examines the modernization of public health genetics programs in state health agencies. The specific aims are to (Aim 1a) describe the conceptual models, organizational structures, and financing solutions that state health agencies are using to modernize public health genetics programs; (Aim 1b) explore the opinions and attitudes of stakeholders about the scope and suitability of state public health genetics programs; (Aim 2a) through a comparative case study, identify the critical elements that impede or promote integration of genetics into public health; and (Aim 2b) explain how public health genetics programs vary under different structural arrangements, and show how the opinions of stakeholders influence public health genetics programming. In response to questions from study section reviewers, this revised application clarifies the sampling strategy and explains the analytic method of the qualitative comparative case study more thoroughly. The research will be based on original data collected via field observation, in-depth interviews, and archival analysis of state public health genetics activities n four states (Michigan, Connecticut, New York, and Utah). Dr. Senier has recruited an interdisciplinary mentor committee to guide her in these training and research activities. Dr. Pila Ossorio (Associate Professor of Law and Bioethics), Dr. Daniel Kleinman (Professor and Chair of Community & Environmental Sociology), Dr. Tom Oliver (Professor of Population Health Sciences), and Dr. D. Paul Moberg, (Director, Population Health Institute) will guide Dr. Senier in these endeavors. At the suggestion of study section reviewers, Dr. Nancy Cox (University of Chicago) and Dr. Peter Conrad (Brandeis University) are joining the mentorship committee to provide additional methodological guidance. Together, this committee of mentors has expertise in the emerging legal and ethical challenges in biotechnology; organizational and political barriers in science policy and health policy; and innovative research methods in comparative case study design and program evaluation research. They are eminently qualified and fully committed to assisting Dr. Senier in her multidisciplinary training, research, and career path.

描述（由申请人提供）：这一修订后的申请辅导研究科学家发展奖（K 01）的目的是支持劳拉·塞尼尔，公共卫生硕士，博士，助理教授在威斯康星大学麦迪逊分校的职业生涯。Senier博士的目标是（1）获得人口遗传学，公共政策分析和管理新兴遗传技术的伦理框架的额外培训;（2）建立一个研究计划，探索将遗传发现转化为公共卫生政策和计划的技术，政治和伦理障碍;（3）成为研究翻译政治的独立调查员。Senier博士将通过正式课程，指导合作和对国家公共卫生政策的实证研究相结合来实现这些目标。该研究计划审查了国家卫生机构公共卫生遗传学项目的现代化。具体目标是（目标1a）描述的概念模型，组织结构，和国家卫生机构正在使用的现代化公共卫生遗传学计划的融资解决方案;（目标1b）探讨利益相关者的意见和态度的范围和国家公共卫生遗传学计划的适用性;（目标2a）通过比较个案研究，确定阻碍或促进将遗传学纳入公共卫生的关键因素;和（目标2b）解释公共卫生遗传学计划在不同的结构安排下如何变化，并说明利益相关者的意见如何影响公共卫生遗传学计划。为了回应研究部分评审员的问题，本修订申请澄清了抽样策略，并更彻底地解释了定性比较案例研究的分析方法。这项研究将基于通过实地观察、深入访谈和对四个州（密歇根州、康涅狄格州、纽约州和犹他州）公共卫生遗传学活动的档案分析收集的原始数据。Senier博士已经招募了一个跨学科的导师委员会来指导她进行这些培训和研究活动。Pila Ossorio博士（法律和生物伦理学副教授），丹尼尔克莱曼博士（教授和社区与环境社会学主席），汤姆奥利弗博士（人口健康科学教授）和D. Paul Moberg（人口健康研究所所长）将指导Senier博士开展这些工作。在研究部分评审员的建议下，南希考克斯博士（芝加哥大学）和彼得康拉德博士（布兰迪斯大学）将加入导师委员会，提供额外的方法指导。总的来说，这个导师委员会在生物技术中新兴的法律的和伦理挑战方面具有专业知识;科学政策和卫生政策中的组织和政治障碍;以及比较案例研究设计和项目评估研究中的创新研究方法。他们非常有资格，并完全致力于协助博士Senier在她的多学科培训，研究和职业道路。