RESEARCH EDUCATION PROGRAM ON COMPUTATIONAL AND STATISTICAL TOOL DEVELOPMENT FOR ADDICTION GENETICS

成瘾遗传学计算和统计工具开发研究教育计划

• 批准号: 8915941
• 负责人: Pamela Ann Madden
• 金额: $ 44.97万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8915941
• 关键词: Advisory Committees; Alcohol or Other Drugs use; Animal Model; Area; Award; Basic Science; Bioinformatics; Biological Psychiatry; Biometry; Cells; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Computational Biology; Computer software; Computing Methodologies; Critiques; Data; Development; Development Plans; Disease; Documentation; Drug Addiction; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Environment; Epigenetic Process; Evaluation; Faculty; Family health status; Feedback; Fellowship; Generations; Genetic; Genetic Predisposition to Disease; Genetic Research; Genomics; Goals; Human; Illicit Drugs; Individual; Institutional National Research Service Award; Investments; Life; Link; Mathematics; Medical Genetics; Mentors; Methods; Modeling; Online Systems; Other Genetics; Participant; Persons; Phase; Postdoctoral Fellow; Postdoctoral Individual National Research Service Award; Procedures; Program Development; Program Evaluation; Psychology; Public Health; Qualifying; Recording of previous events; Recruitment Activity; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Resources; Risk; Role; Science; Scientist; Statistical Methods; Talents; Testing; Tissues; Tobacco Dependence; Training; Training Programs; Training and Education; Translating; United States National Institutes of Health; Universities; Washington; Work; addiction; computer science; epigenomics; experience; flexibility; genetic epidemiology; genome wide association study; infrastructure development; innovation; interest; member; neuroimaging; novel therapeutic intervention; operation; outreach program; post-doctoral training; programs; public health relevance; quality assurance; responsible research conduct; success; symposium; tool; tool development

 DESCRIPTION (provided by applicant): This R25 application seeks a final 5 years to continue development of a research education program (REP) focused on training in the development of computational, and statistical tools or methods to advance human addiction genetic research. By making such tools widely available (after appropriate pretesting and QC) and training a new generation of computational/statistical scientists motivated to pursue problems in addiction genetics research, the program seeks both to maximize the payoff from existing GWAS and genetic epidemiologic studies of substance use (`addiction') disorders, and to facilitate new directions in human addiction genomics research (e.g., emphasizing epigenetic mechanisms, tissue or cell-specific effects). Consistent with the flexibility of the R25 (compared to T/F) mechanisms, the non-traditional backgrounds of postdoctoral trainees (e.g., bioinformatics, computer science, statistical genetics), and the requirement to produce and share innovative tools and methods, the REP proposes a 4-year training model with 3 existing postdocs, and 4 new postdocs to be recruited during the first two years of award. The program recruits postdoctoral trainees globally to identify candidates of exceptional talent and energy, and pairs them with an exceptional, diverse and highly collaborative faculty, reflected in the significant an highly innovative contributions of current and former trainees (e.g., 0.5 million hits per month fo one web-based tool). The program takes advantage of an exceptional institutional environment, Washington University being a leader in genomics research (including epigenomics), in statistical genetics and genomics, and in biological psychiatry research (including psychiatric - and especially addiction - genetics research). It uses a research apprenticeship training model, in which a trainee is paired with a primary mentor with pertinent expertise in computational biology/statistical genomics or genetics research who has identified a problem that can advance human addiction genetics research; one or more co-mentors with strong backgrounds as clinical researchers focused on addiction genetics; and external consultants who can supplement the expertise of the mentoring team (e.g., animal models). Formal coursework at Washington University and workshops attended elsewhere in addiction research, in responsible conduct of research, and other didactics tailored to strengthen academic background (e.g., genomics, computer science) are used to advance the research education of individual postdoctoral trainees. The program is led by directors with backgrounds in addiction genetics, statistical genetics/genomics and computational biology with histories of successful collaboration. The implementation and refinement of the REP is guided by a strong Internal Program Advisory Committee with annual feedback and critique from an outstanding External Advisory Board, and from consultant participants in biennial postdoctoral symposia. We promote ongoing collaboration of addiction, statistical genetics and computational biology scientists in research and in research education beyond the life of the R25.

 该R25申请寻求最后5年继续开发研究教育计划（REP），重点是开发计算和统计工具或方法的培训，以推进人类成瘾遗传研究。通过广泛提供这些工具（经过适当的预测试和质量控制）和培训新一代有动力追求成瘾遗传学研究问题的计算/统计科学家，该计划旨在最大限度地提高现有GWAS和物质使用（“成瘾”）疾病遗传流行病学研究的回报，并促进人类成瘾基因组学研究的新方向（例如，强调表观遗传机制、组织或细胞特异性效应）。与R25（与T/F相比）机制的灵活性相一致，博士后学员的非传统背景（例如，为了满足生物信息学、计算机科学、统计遗传学等学科的发展需求，以及生产和分享创新工具和方法的要求，REP提出了一个为期4年的培训模式，其中包括3名现有的博士后，以及在奖励的前两年招募4名新的博士后。该计划在全球范围内招募博士后学员，以确定具有特殊才能和能量的候选人，并将他们与特殊，多样化和高度协作的教师配对，这反映在现任和前任学员的重大高度创新贡献中（例如，0.5一个基于网络的工具每月点击百万次）。该计划利用了特殊的机构环境，华盛顿大学是基因组学研究（包括表观基因组学），统计遗传学和基因组学以及生物精神病学研究（包括精神病-特别是成瘾-遗传学研究）的领导者。它采用研究学徒培训模式，其中受训者与具有计算生物学/统计基因组学或遗传学研究相关专业知识的主要导师配对，他们已经确定了可以推进人类成瘾遗传学研究的问题;一名或多名具有强大背景的共同导师，作为专注于成瘾遗传学的临床研究人员;以及可以补充指导团队专业知识的外部顾问（例如，动物模型）。华盛顿大学的正式课程和其他地方参加的成瘾研究、负责任的研究行为以及其他为加强学术背景而量身定制的教学法（例如，基因组学、计算机科学）用于推进博士后个人的研究教育。该计划由具有成瘾遗传学，统计遗传学/基因组学和计算生物学背景的董事领导，具有成功合作的历史。REP的实施和完善由一个强大的内部计划咨询委员会指导，该委员会每年都有来自杰出的外部咨询委员会的反馈和批评，以及两年一度的博士后研讨会的顾问参与者。我们促进成瘾，统计遗传学和计算生物学科学家在研究和研究教育方面的持续合作，超越了R25的生命。