PREVENTION-CONTROL

项目总结（见说明）： 癌症预防和控制计划（PC）的成员进行人口科学和化学预防研究，具有显着的潜力，以减少癌症负担在科罗拉多，落基山脉地区和超越。PC有三个主要的重点小组：1）一级和二级预防的行为研究，2）化学预防研究，3）癌症结局和癌症生存率研究。在目前的CCSG计划中，成员们为科学做出了许多贡献。 癌症预防和控制，包括：1）几项大型研究临床试验（RCT），证明了定制印刷材料在促进水果和蔬菜消费、结直肠癌筛查和戒烟方面的功效; 2）一项大型学校计划和一项针对户外冬季娱乐业的巨大努力，成功地促进了防晒; 3）一个强大的实验室研究计划，已经证明了水飞蓟宾在动物中的化学预防特性， 前列腺癌、肺癌、结肠直肠癌和膀胱癌的模型，以及前列腺癌和结肠癌的葡萄籽提取物; 4）一项大型多中心RCT，证明电话咨询对乳腺癌幸存者心理社会结局的有效性; 5）一项大型多中心RCT，证明儿童癌症年轻幸存者认知补救计划的有效性; 6）两个最权威的癌症流行病学研究项目，检查并确定了乳腺癌的危险因素 拉丁美洲人中的癌症研究，以及科罗拉多幼儿中的痣发展，以及7）在防晒、饮食、营养和体育活动、烟草控制、结肠直肠癌筛查和化学预防研究领域的转化科学和传播研究的众多范例。PC包括31名正式成员和32名准成员，来自科罗拉多丹佛大学、科罗拉多博尔德大学、退伍军人管理局（丹佛）、 科罗拉多州立大学、丹佛健康医疗中心、儿童医院（丹佛）和科罗拉多的凯撒医疗机构。在当前的CCSG期间，项目成员发表了594篇同行评审的癌症相关论文，而上一届CCSG期间为306篇。这些出版物中有37%是合作出版的，23%是方案间出版的或方案间和方案内出版的。同行评审的癌症相关资金也从890万美元（2005年）增加到2010年的1 330万美元。这意味着人均增长了140%，从26.9万美元增加到64万美元。

PROJECT SUMMARY (See instructions): Members of the Cancer Prevention and Control Program (PC) conduct population sciences and chemoprevention research that has significant potential to reduce the cancer burden in Colorado, the Rocky Mountain Region and beyond. PC has three main focus groups: 1) behavioral research in primary and secondary prevention, 2) chemoprevention research, and 3) cancer outcomes and cancer survivorship research. During the current CCSG program members have made numerous contributions to the science of cancer prevention and control, including: 1) several large research clinical trials (RCTs) that have demonstrated the efficacy of tailored print materials to promote fruit and vegetable consumption, colorectal cancer screening and smoking cessation; 2) a large school-based program and a monumental effort that targeted the outdoor winter recreation industry that successfully promoted sun protection; 3) a robust program of laboratory research that has demonstrated the chemoprevention properties of silibinin in animal models for prostate, lung, colorectal, and bladder cancer, as well as grape seed extract for prostate and colon cancer; 4) a large multi-site RCT demonstrating the efficacy of telephone counseling on psychosocial outcomes among breast cancer survivors; 5) a large multi-site RCT that demonstrated the efficacy of a cognitive remediation program for young survivors of childhood cancer; 6) two of the most definitive programs of research in cancer epidemiology that have examined and identified risk factors for breast cancer among Latinas, and nevus development among young children in Colorado, and 7) numerous exemplars of translational science and dissemination research in the areas of sun protection, diet, nutrition and physical activity, tobacco control, colorectal cancer screening and chemoprevention research. PC includes 31 Full Members and 32 Associate Members drawn from 17 academic departments and schools within the University of Colorado Denver, University of Colorado Boulder, the Veterans Administration (Denver), Colorado State University, Denver Health Medical Center, The Children's Hospital (Denver) and Kaiser Permanente of Colorado. During the current CCSG, program members have published 594 peer-reviewed cancer-related papers, compared to 306 during the previous CCSG. 37% of these publications were collaborative, with 23% being interprogrammatic or both interprogrammatic and intraprogrammatic. Peer reviewed, cancer-related funding has also increased from $8.9M (2005) to $13.3M in 2010. This represents a per capita increase of 140% from $269K to over $640K per member.