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DNA HYPOMETHYLATION AND CORTICAL NEURONAL DEGENERATION

DNA HYPOMETHYLATION AND CORTICAL NEURONAL DEGENERATION
DNA 低甲基化和皮质神经元变性
批准号:
8129422
负责人:
Guoping Fan
金额:
$38.5万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-03-15 至 2011-08-31
关键词:
Aberrant DNA MethylationAddressAdultAgeAnimal ModelApoptosisAstrocytesBDNF geneBehaviorBinding ProteinsBioinformaticsBiological ModelsBrainBrain regionCell Differentiation processCentromereDNADNA MethylationDNA MethyltransferaseDNA Modification MethylasesDNA Modification ProcessDataDefectDevelopmentDiscipline of NursingDiseaseEnzymesEpigenetic ProcessExhibitsFaceFunctional disorderGene ExpressionGene Expression RegulationGenesGenomic ImprintingGlial DifferentiationGrantHereditary DiseaseHippocampal FormationHippocampus (Brain)Human GeneticsImmunologic Deficiency SyndromesKnock-outKnowledgeLeadLearningLimbic SystemMaintenanceMalignant NeoplasmsMammalsMapsMediatingMemoryMental RetardationMethyl-CpG-Binding Protein 2MethylationMolecularMolecular Biology TechniquesMorphologyMusMutant Strains MiceMutationNerve DegenerationNeuraxisNeuronal PlasticityNeuronsNucleotidesOligodendrogliaPatientsPatternPhenotypePlayPromoter RegionsProsencephalonProteinsPublic HealthRegulationRegulator GenesRegulatory PathwayResearchResolutionRett SyndromeRoleShotgunsStimulusStructureSynaptic plasticitySyndromeTechnologyTransgenic MiceUp-RegulationX Inactivationadult neurogenesisbasebisulfitebrain celldentate gyrusexcitatory neurongenome-widehistone modificationhuman diseaseinsightlong term memorymembermotor neuron functionmutantnervous system developmentnervous system disordernestin proteinneural precursor cellneurodevelopmentneuron developmentneuronal survivalneurophysiologyneuropsychiatrynext generationnovelpostnatalprecursor cellrelating to nervous systemresponseyoung adult

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