Postdoctoral Research Training in Pediatric Clinical Pharmacology

描述（由申请人提供）：迫切需要在儿科临床药理学方面受过正规培训的临床科学家。没有训练有素的调查人员，为个别儿童优化使用药物的目标是无法实现的。印第安纳大学儿科和临床药理学部门是唯一的定位，以解决这一需求。一个强大的、成熟的临床药理学研究小组的优势在于，它毗邻美国最强大的儿科研究环境之一：莱利儿童医院，其儿科一直排在NIH资助的前10名。该申请旨在建立一个正式的儿科临床药理学和治疗学培训计划，与我们长期的临床药理学培训计划并行，该计划在培训成功的转化临床医生科学家方面有着卓越的记录。印第安纳大学儿科临床与发展药理学博士后研究培训有三个主要组成部分：1)完成两到三年的正式教学课程，结束后学员可以获得临床研究硕士学位；2)组织儿童参加个性化治疗系列研讨会和每周期刊俱乐部；3)在与该项目相关的一名教员的指导下积极参与儿科治疗学研究。该计划的教师根据他们作为临床科学家的潜力从具有医学博士或医学博士/博士学位的候选人中选择2至3年的培训生，这些候选人符合初级专业认证的资格。可能会选择具有与该计划目标相关的经验和目标的杰出博士或药学博士候选人。我们建议在任何给定时间支持三名博士后。完成该课程的学生将在临床和转化研究方法、生物统计学、临床试验、研究伦理、科学写作和拨款写作方面培养核心能力。他们还将获得一个结构化的研究指导计划，该计划有明确的时间表和基准。所有受训者都必须参加一系列教学讲座，重点是药物动力学、药物基因组学、药物开发、个体化治疗和临床试验设计。学员还可以参加由印第安纳州CTSI支持的临床研究者培训增强计划，并获得临床研究硕士学位。课程与监督研究经验相结合，将培养出一支训练有素的研究人员队伍，他们具有广泛、深入、前沿的培训经验，为儿科临床和转化药理学的成功职业做好准备。莱利医院庞大、多样化的患者群体，加上大型、前沿的临床药理学培训项目和威尔斯儿科研究中心所赋予的深度、广度和灵活性，为在这个新兴领域培养领导者的重点培训项目中学习儿科临床药理学提供了一个绝佳的机会。

DESCRIPTION (provided by applicant): A critical need exists for a robust supply of clinician scientists with formal training in pediatric clinical pharmacology. Without trained investigators the goal of optimizing use of medications for individual children cannot be realized. The Indiana University Department of Pediatrics and Division of Clinical Pharmacology are uniquely positioned to address this need. A strong, well-established group of clinical pharmacology investigators has the advantage of being located directly adjacent to one of the strongest pediatric research environments in the US: Riley Hospital for Children, with a Department of Pediatrics consistently ranked in the top 10 in NIH funding. This application seeks to establish a formal pediatric clinical pharmacology and therapeutics training program in parallel with our long-standing clinical pharmacology training program, which has a track record of excellence in training successful translational clinician scientists. There are three main components to the Indiana University Postdoctoral Research Training in Pediatric Clinical and Developmental Pharmacology: 1) completion of a two to three year formal didactic curriculum, at the end of which the trainee may receive a master's degree in clinical research; 2) organized pediatric participation in a personalized therapeutics seminar series and weekly journal club; and 3) active involvement in pediatric therapeutics research under the mentorship of one of the faculty members associated with the program. The program faculty selects trainees for the 2 to 3 year program based on their potential as clinician scientists from candidates with MD or MD/ PhD degrees who qualify for primary specialty certification. Exceptional PhD or PharmD candidates with experience and goals related to the objectives of the program may be selected. We propose supporting a total of three postdoctoral fellows at any given time. Those who complete the program will develop core competencies in clinical and translational research methods, biostatistics, clinical trials, research ethics, scientific writing, and grant writing. They will also be provided with a structured research mentoring program with an explicit timeline and benchmarks. In depth training focusing on pharmacokinetics, pharmacogenomics, drug development, individualized therapeutics, and clinical trial design is included in a didactic lecture series required of all trainees. Trainees may also participate in the Clinical Investigator Training Enhancement program supported by the Indiana CTSI and resulting in an MS in Clinical Investigation. Coursework combined with supervised research experience will result in development of a highly trained cadre of investigators with broad, deep, cutting edge training experiences preparing them for successful careers in pediatric clinical and translational pharmacology. The large, diverse patient population at Riley Hospital coupled with the depth, breadth and flexibility imparted by a large, cutting edge Clinical Pharmacology training program and the Wells Center for Pediatric Research offer an exceptional opportunity to study pediatric clinical pharmacology within a focused training program designed to generate leaders in this emerging field. PUBLIC HEALTH RELEVANCE: The Indiana University Postdoctoral Research Training in Pediatric Clinical and Developmental Pharmacology proposed in this application is located in an ideal environment with a well-established Division of Clinical Pharmacology and a large, free-standing pediatric hospital with multiple funded investigators. We expect that the synergy created by this partnership will generate leaders in the field of pediatric clinical pharmacology.