Postdoctoral Research Training in Pediatric Clinical Pharmacology

儿科临床药理学博士后研究培训

• 批准号: 8458124
• 负责人: DAVID Alastair FLOCKHART
• 金额: $ 19.88万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8458124
• 关键词: Childhood; Clinical Pharmacology; Research Training

DESCRIPTION (provided by applicant): A critical need exists for a robust supply of clinician scientists with formal training in pediatric clinical pharmacology. Without trained investigators the goal of optimizing use of medications for individual children cannot be realized. The Indiana University Department of Pediatrics and Division of Clinical Pharmacology are uniquely positioned to address this need. A strong, well-established group of clinical pharmacology investigators has the advantage of being located directly adjacent to one of the strongest pediatric research environments in the US: Riley Hospital for Children, with a Department of Pediatrics consistently ranked in the top 10 in NIH funding. This application seeks to establish a formal pediatric clinical pharmacology and therapeutics training program in parallel with our long-standing clinical pharmacology training program, which has a track record of excellence in training successful translational clinician scientists. There are three main components to the Indiana University Postdoctoral Research Training in Pediatric Clinical and Developmental Pharmacology: 1) completion of a two to three year formal didactic curriculum, at the end of which the trainee may receive a master's degree in clinical research; 2) organized pediatric participation in a personalized therapeutics seminar series and weekly journal club; and 3) active involvement in pediatric therapeutics research under the mentorship of one of the faculty members associated with the program. The program faculty selects trainees for the 2 to 3 year program based on their potential as clinician scientists from candidates with MD or MD/ PhD degrees who qualify for primary specialty certification. Exceptional PhD or PharmD candidates with experience and goals related to the objectives of the program may be selected. We propose supporting a total of three postdoctoral fellows at any given time. Those who complete the program will develop core competencies in clinical and translational research methods, biostatistics, clinical trials, research ethics, scientific writing, and grant writing. They will also be provided with a structured research mentoring program with an explicit timeline and benchmarks. In depth training focusing on pharmacokinetics, pharmacogenomics, drug development, individualized therapeutics, and clinical trial design is included in a didactic lecture series required of all trainees. Trainees may also participate in the Clinical Investigator Training Enhancement program supported by the Indiana CTSI and resulting in an MS in Clinical Investigation. Coursework combined with supervised research experience will result in development of a highly trained cadre of investigators with broad, deep, cutting edge training experiences preparing them for successful careers in pediatric clinical and translational pharmacology. The large, diverse patient population at Riley Hospital coupled with the depth, breadth and flexibility imparted by a large, cutting edge Clinical Pharmacology training program and the Wells Center for Pediatric Research offer an exceptional opportunity to study pediatric clinical pharmacology within a focused training program designed to generate leaders in this emerging field.

描述(由申请人提供)：存在着对具有儿科临床药理学正规培训的临床科学家的强劲供应的迫切需求。如果没有训练有素的调查人员，就不可能实现为个别儿童优化药物使用的目标。印第安纳大学儿科和临床药理学分部在满足这一需求方面具有独特的地位。一支强大的、久负盛名的临床药理学研究团队的优势在于，它直接毗邻美国最强大的儿科研究环境之一：莱利儿童医院，其儿科部门一直位居NIH资助的前10名。这项申请旨在建立一个正式的儿科临床药理学和治疗学培训计划，与我们长期的临床药理学培训计划并行，该计划在培训成功的临床医生科学家方面有着卓越的记录。印第安纳大学的儿科临床和发育药理学博士后研究培训有三个主要部分：1)完成两到三年的正规教学课程，学员可以在完成课程后获得临床研究硕士学位；2)组织儿科参加个性化治疗学系列研讨会和每周期刊俱乐部；以及3)在与该计划相关的一名教员的指导下积极参与儿科治疗学研究。该计划的教职员工根据他们作为临床科学家的潜力，从有资格获得初级专业认证的拥有医学或医学/博士学位的候选人中挑选2至3年期计划的实习生。具有与项目目标相关的经验和目标的博士或药学博士候选人可被选中。我们建议在任何给定时间总共支持三名博士后研究员。完成该计划的学生将在临床和转化性研究方法、生物统计学、临床试验、研究伦理、科学写作和拨款撰写方面发展核心能力。他们还将获得一个有明确时间表和基准的结构化研究指导计划。所有学员都需要进行一系列教学讲座，内容包括药代动力学、药物基因组学、药物开发、个体化疗法和临床试验设计等。学员还可以参加由印第安纳州CTSI支持的临床研究人员培训强化计划，并获得临床调查硕士学位。课程工作与受监督的研究经验相结合，将培养一支训练有素的调查人员队伍，他们具有广泛、深入的尖端培训经验，为他们在儿科临床和转化药理学领域的成功职业生涯做好准备。莱利医院庞大多样的患者群体，加上大型尖端临床药理学培训计划和威尔斯儿科研究中心所赋予的深度、广度和灵活性，为在旨在培养这一新兴领域领导者的重点培训计划中学习儿科临床药理学提供了难得的机会。