Interdisciplinary Training in Pathobiology and Rehabilitation Medicine

描述（由申请人提供）：该培训计划的总体目标是将新兴科学家培养成转化康复研究的未来领导者，他们专门配备测试和传播新的康复策略，以减轻慢性病管理中的功能障碍和生活质量受损。这一目标将通过利用一个非常丰富的机构环境来实现，该环境提供了无数的资源以及一个致力于培训和职业发展的基础和临床研究导师的互补和协作团队。博士前和博士后学员将受益于两年的跨学科培训，精心融合了三个核心水平的科学探究：i）疾病的细胞和分子病理学; ii）康复 科学和运动生理学;以及iii）康复医学（即临床试验）。训练将发生在两个集中力量的领域之一：1）神经肌肉骨骼和运动障碍;或2）心脏病和代谢疾病。有培训机会的交叉主题包括癌症和老龄化。博士前学员将从一个高度竞争和多样化的国家学生库中选择，这些学生将被录取到研究生生物医学科学课程或康复科学课程。全国招募的博士后学员将通过博士后教育办公室和临床和转化科学中心赞助的结构化计划和课程获得宝贵的临床和转化研究培训和职业发展。每个学员的主要导师和翻译导师团队将从医学院（生理学，物理医学和康复，神经病学，细胞生物学，病理学，遗传学，心脏病学，老年病学），健康护理（物理治疗，职业治疗和营养科学），公共卫生（流行病学）和艺术与科学（心理学）的专家课程教师中抽取。学员、导师和翻译指导团队将共同制定个人发展计划，并由执行委员会每半年批准和监督一次。该计划将包括必修和选修教学课程、实验室和临床研究、期刊俱乐部、研讨会、在当地和国家会议上的科学介绍以及负责任地进行研究的培训。学习进行和发表高影响力的研究将是培训计划的主要重点。博士后学员也将受益于赠款写作和实验室管理课程。该计划将从第一年指导两名博士前和两名博士后学员发展到每年四名，并将采取 成功征聘代表性不足的少数群体和残疾人的既定最佳做法的优势。作为美国国立卫生研究院资助的前25名学术医疗中心，拥有80多个最先进的科学核心设施和25个大学范围内的跨学科研究中心，亚拉巴马大学伯明翰分校非常适合培养真正的转化科学家，他们能够通过尖端研究推动康复医学领域。

DESCRIPTION (provided by applicant): The overarching goal of this training program is to develop burgeoning scientists into future leaders in translational rehabilitation research who are specifically equipped to test and disseminate novel rehabilitative strategies that will alleviate functional impairment and compromised life quality in the face of chronic disease management. This goal will be met by taking advantage of an exceptionally rich institutional environment that offers myriad resources and a complementary and collaborative team of basic and clinical research mentors committed to training and career development. Predoctoral and postdoctoral trainees will benefit from two years of interdisciplinary training that carefully meld three core levels of scientific inquiry: i) cellular and molecular pathobiology of disease; ii) rehabilitation science and exercise physiology; and iii) rehabilitation medicine (i.e. clinical trials). Training ill occur in one of two areas of concentrated strength: 1) Neuromusculo- skeletal and Movement Disorders; or 2) Cardiopulmonary and Metabolic Diseases. Cross-cutting themes with training opportunities include cancer and aging. Predoctoral trainees will be selected from a highly competitive and diverse national pool of students admitted to either the Graduate Biomedical Sciences program or Rehabilitation Science program. Nationally recruited postdoctoral trainees will gain invaluable clinical and translational research training and career development via structured programs and courses sponsored by the Office of Postdoctoral Education and the Center for Clinical and Translational Science. Each trainee's primary mentor and Translational Mentoring Team will be drawn from expert program faculty in the Schools of Medicine (physiology, physical medicine & rehabilitation, neurology, cell biology, pathology, genetics, cardiology, geriatrics), Health Professions (physical therapy, occupational therapy, and nutrition sciences), Public Health (epidemiology), and Arts & Sciences (psychology). Together the trainee, mentor, and Translational Mentoring Team will craft an individual development plan, which will be approved and monitored semi-annually by the Executive Committee. The plan will include required and elective didactic courses, laboratory and clinical research, journal clubs, seminars, scientific presentations locally and at national meetings, and training in the responsible conduct of research. Learning to conduct and publish high-impact research will be a primary focus of the training program. Postdoctoral trainees will also profit from courses on grant writing and laboratory management. The program will grow from mentoring two predoctoral and two postdoctoral trainees in the first year to four of each annually, and will take advantage of well-established best practices for successful recruitment of underrepresented minorities and individuals with disabilities. As a top 25 NIH-funded academic medical center with over 80 state-of-the-art scientific core facilities and 25 University-wide, interdisciplinary reseach centers, the University of Alabama at Birmingham is remarkably well-positioned to cultivate truly translational scientists equipped to drive the field of rehabilitation medicine with cutting edge research.