Artificial Lung Based on a Novel Microfluidic Technology

描述（由申请人提供）：肺移植仍然是许多疾病的最终治疗方法。然而，合适和可用的肺远远少于需要它们的人数，这使得许多患者在等待移植时进一步恶化或死亡。此外，还有许多肺功能不足的患者，包括那些患有肺癌的患者，他们没有资格进行肺移植。空气和血液之间的直接气体交换将提供独立于受伤肺部的呼吸支持，并允许肺部愈合和恢复。可以使用室内空气而不是压缩空气进行呼吸并且具有足够小的血液侧压降的装置将极大地简化和改善体外氧合。随着长期安全性和有效性的增加，这种设备将实现完全植入式人工肺的最终目标。Infoscitex已经组建了一个专家团队，以进一步开发血管气体交换设备系列的技术。这些器械使用可用的室内空气，与目前可用或正在开发的其他器械相比，可能会减少对抗凝方法的需求。本提案中详细介绍的研究计划将为完成植入式人工肺技术的开发提供必要的基础，包括初步的动物试验。拟议的努力将产生必要的数据，以确保下一阶段的设备开发和最终上市的资金和批准。 公共卫生相关性：提出了一种基于直接从室内空气进行直接血管气体交换并需要低水平抗凝的植入式人工肺的发展。我们的设备采用了一种新型的两阶段气体交换系统，通过液-液界面氧合血液。通过消除血液与膜的接触，该界面减少了气体交换表面的污染，这是正在开发的其他装置中的限制因素。

DESCRIPTION (provided by applicant): Lung transplants remain the final treatment for many conditions. However, appropriate and available lungs are far fewer than the number of people who need them, leaving many patients to further deterioriate or die while waiting for a transplant. Moreover, there are many patients with insufficient lung function, including those suffering from lung cancer, who are not eligible for a lung transplant. Direct gas exchange between air and blood would provide respiratory support independent of injured lungs and allow the lungs to heal and recover. A device that can oxygenate using room air, rather than compressed air, and has a sufficiently small blood side pressure drop would greatly simplify and improve extracorporeal oxygenation. With the added requirements of long-term safety and efficacy, such a device would realize the final goal of a fully implantable artificial lung. Infoscitex has assembled a team of experts to further develop the technology for a family of vascular gas exchange devices. These devices use available room air and will likely reduce the need for anticoagulation methods compared to other devices currently available or in development. The research program detailed in this proposal will provide the necessary foundation to complete development of the technology for the implantable artificial lung, including initial animal trials. The proposed effort will result in the data necessary to secure the funding and approval for the next stage of device development and eventual market introduction. PUBLIC HEALTH RELEVANCE: The development of an implantable artificial lung based on direct vascular gas exchange performed directly from room air and requiring low levels of anticoagulation is proposed. Our device utilizes a novel two-stage gas exchange system that oxygenates blood via a liquid-liquid interface. This interface, by eliminating the contact of blood to a membrane, reduces fouling of the gas exchange surface which is the limiting factor in other devices under development.