Peptide Therapy for Pulmonary Arterial Hypertension

肺动脉高压的肽疗法

• 批准号: 8195592
• 负责人: JAWAHARLAL M. PATEL
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195592
• 关键词: 1-Phosphatidylinositol 3-Kinase; 3-Phosphoinositide Dependent Protein Kinase-1; Adult Respiratory Distress Syndrome; Altitude; Amino Acid Sequence; Amino Acids; Animal Model; Arteries; Attenuated; Binding; Biological Availability; Blood Vessels; Blood flow; Cardiac; Cardiac Output; Chemicals; Chronic; Chronic Obstructive Airway Disease; Clinical; Clinical Treatment; Combined Modality Therapy; Conscious; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Data; Development; Disease; Dissociation; Dose; Etiology; Event; Exposure to; Failure; Functional disorder; GTP-Binding Proteins; Guanosine; HIV Infections; Health; Heart; Heart Diseases; Heart failure; Hematocrit procedure; Human; Human Resources; Hydrolysis; Hypertension; Hypoxia; Implant; Injury; Investigational Therapies; Lead; Legal patent; Low Cardiac Output; Lung; Lung diseases; Medial; Mediating; Mediator of activation protein; Modeling; Molecular; Monitor; Morbidity - disease rate; Motion; Nitric Oxide; Nitric Oxide Synthase; Obesity; Obstruction; Patients; Peptide Sequence Determination; Peptides; Pharmaceutical Preparations; Phase I Clinical Trials; Phosphorylation; Phosphotransferases; Physiological; Play; Population; Prevalence; Production; Proto-Oncogene Proteins c-akt; Pulmonary Circulation; Pulmonary Vascular Resistance; Pulmonary artery structure; Rattus; Regimen; Regulation; Reporting; Right Ventricular Hypertrophy; Right lung; Right ventricular structure; Risk Factors; Role; Route; Schistosomiasis; Signal Transduction; Smoking; Smooth Muscle Myocytes; Telemetry; Testing; Therapeutic; Therapeutic Agents; Thick; Toxic effect; Toxin; Treatment Efficacy; Vascular Diseases; Vascular Endothelial Cell; Vascular Endothelium; Vascular remodeling; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Ventricular; Veterans; base; caveolin 1; cigarette smoking; clinically relevant; combat; experience; hemodynamics; human NOS3 protein; improved; indexing; inhibitor/antagonist; innovation; intraperitoneal; knockout animal; lung injury; mortality; novel; novel strategies; novel therapeutic intervention; patient population; peptide P3; phosphoric diester hydrolase; pre-clinical; pressure; pulmonary arterial hypertension; pulmonary artery endothelial cell; response; sildenafil; subcutaneous; success; synthetic peptide; treatment strategy; vascular endothelial dysfunction; vasoconstriction