Mechanisms of Impaired Wound Healing Due to Ischemia

缺血导致伤口愈合受损的机制

• 批准号: 7903899
• 负责人: Lisa J Gould
• 金额: --
• 依托单位: JAMES A. HALEY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2012-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7903899
• 关键词: 3-nitrotyrosine; Acute; Affect; Age; Age-Months; Aged, 80 and over; Aging; American; Anti-Inflammatory Agents; Anti-inflammatory; Antioxidants; Apoptosis; Biological Assay; Biological Availability; Buffers; Cell Death; Cell Proliferation; Cell Survival; Cell physiology; Cells; Chronic; Collagen; Comorbidity; Confocal Microscopy; Cuprozinc Superoxide Dismutase; Data; Diabetes Mellitus; Elderly; Endothelial Cells; Enzymes; Epidemic; Epithelial Cells; Equilibrium; Excision; Extracellular Matrix; Fibroblasts; Foundations; Gelatinase B; Generations; Glutamate-Cysteine Ligase; Glutathione; Goals; Healed; Health; Health system; Healthcare; Healthcare Systems; Heart Diseases; Homeostasis; Human; Hydrogen Peroxide; Hyperoxia; Hypoxia; Immunoblotting; Immunohistochemistry; Impaired wound healing; Incidence; Indium; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Intermittent Claudication; Interstitial Collagenase; Ischemia; Isoenzymes; Lead; Life; Limb structure; Liquid substance; Literature; Lower Extremity; Lucigenin; Matrix Metalloproteinase Inhibitor; Matrix Metalloproteinases; Measurement; Measures; Messenger RNA; Modeling; Molecular; Morbidity - disease rate; NBL1 gene; Natural regeneration; Necrosis; Nitrates; Nitric Oxide; Nitrites; Nitrogen; Oxidation-Reduction; Oxidative Stress; Oxygen; Pathogenesis; Pathology; Patients; Peptide Hydrolases; Perfusion; Peripheral arterial disease; Peroxonitrite; Physiological; Play; Population; Predisposition; Prevalence; Procedures; Process; Production; Protease Inhibitor; Protein Isoforms; Proteins; Public Health; Rattus; Reaction; Reactive Nitrogen Species; Reactive Oxygen Species; Reperfusion Therapy; Residual state; Role; Signaling Molecule; Skin; Skin Aging; Stress; Superoxide Dismutase; Superoxides; Surgical Flaps; System; Testing; Time; Tissue Extracts; Tissue Model; Tissues; Vascular Diseases; Vascular blood supply; Venous Insufficiency; Veterans; Water; Wound Healing; abstracting; angiogenesis; catalase; cell motility; cost; cytokine; effective therapy; enzyme activity; healing; improved; inhibitor/antagonist; keratinocyte; mRNA Expression; middle age; migration; mimetics; nitration; novel; oxidation; oxidative damage; pressure; prevent; protein expression; response; superoxide dismutase 1; synthetic enzyme; tissue trauma; wound; young adult