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Alpha-synuclein RNAi in a model of sporadic Parkinson's disease

Alpha-synuclein RNAi in a model of sporadic Parkinson's disease
散发性帕金森病模型中的 α-突触核蛋白 RNAi
批准号：
7907871
负责人：
Edward Alan Burton
金额：
$0.0万
依托单位：
VETERANS HEALTH ADMINISTRATION
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2012-09-30
来源：
https://reporter.nih.gov/project-details/7907871
关键词：
AdultAffectAgingAnimalsBehaviorBehavioralBiochemicalBiological PreservationBladderBrainBrain regionCell RespirationCell SurvivalCellsCessation of lifeCharacteristicsChronicComplexCorpus striatum structureCytoplasmic InclusionDataDefectDevelopmentDiseaseDisease ProgressionDopamineDrug Delivery SystemsFamilyFutureGene ExpressionGene TargetingGoalsImpairmentIn VitroInjuryIntestinesKnockout MiceLesionLewy BodiesMeasuresMediator of activation proteinMemoryMental HealthMetabolismMitochondriaModelingMoodsMorbidity - disease rateMotorMovementNerve DegenerationNeuronsOxidative StressParkinson DiseaseParkinsonian DisordersPathogenesisPathologyPhenotypePopulationPrincipal InvestigatorProteinsRNARNA InterferenceRat-1RattusReagentReportingResearchResourcesRespiratory ChainRoleRotenoneSafetySatellite VirusesSleep DisordersSubstantia nigra structureSymptomsSystemTestingTherapeutic InterventionToxinTranscriptVeteransViral GenesWorkadeno-associated viral vectoralpha synucleinbaseburden of illnessdesigndisabilitydopaminergic neuronfallsgene transfer vectorgenetically engineered virushealth related quality of lifein vivoin vivo Modelinsightintraperitonealmature animalmitochondrial dysfunctionmutantneurobehavioralneurochemistryneuroprotectionneurotransmissionnoveloxidative damagephysical conditioningpreventprogramspublic health relevanceresearch studyresponsesmall hairpin RNAsynucleintherapeutic targettherapy designvector

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  • 批准号：
    10512035
  • 项目类别：
  • 资助金额：
    $0.0万
  • 财政年份：
    2016
  • 负责人：
    Edward Alan Burton
  • 依托单位：
    VETERANS HEALTH ADMINISTRATION
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