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Group I Metabotropic Glutamate Receptors and Epileptogenesis

Group I Metabotropic Glutamate Receptors and Epileptogenesis
I 类代谢型谷氨酸受体和癫痫发生
批准号：
7920225
负责人：
Paul A Rutecki
金额：
$0.0万
依托单位：
WM S. MIDDLETON MEMORIAL VETERANS HOSP
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2013-09-30
来源：
https://reporter.nih.gov/project-details/7920225
关键词：
Action PotentialsAddressAgonistAnimal ModelAntiepileptic AgentsAreaAwarenessBindingBrainBrain InjuriesBrain regionCalciumCalcium Channel BlockersCationsCellsClinicalCraniocerebral TraumaCytoplasmic TailDNADataDevelopmentDominant-Negative MutationDrug effect disorderEpilepsyEpileptogenesisEquilibriumExposure toFrequenciesFunctional disorderFundingGene ExpressionGenerationsGenesGlutamatesGlycineGoalsHippocampus (Brain)Homer 1Homer 1aHumanImmediate-Early GenesInjuryInterneuronsIntractable EpilepsyKindling (Neurology)Knockout MiceL-Type Calcium ChannelsLeadLinkMaintenanceMeasuresMediatingMembraneMemoryMemory DisordersMetabotropic Glutamate ReceptorsModelingMorbidity - disease rateMusN-Methyl-D-Aspartate ReceptorsNeuronsNeurotransmitter ReceptorPathologicPathway interactionsPhenotypePhysiologyPlasticsPlayPopulationPost-Traumatic EpilepsyPost-Traumatic Stress DisordersPotassiumPresynaptic TerminalsPreventionProbabilityProcessProductionPropertyProteinsRNA SplicingRattusReceptor ActivationRecombinant adeno-associated virus (rAAV)RecurrenceRelative (related person)ResearchResistanceRoleSecond Messenger SystemsSeizuresSliceStatus EpilepticusStrokeSynapsesSynaptic MembranesSynaptic PotentialsSynaptic ReceptorsSynaptic TransmissionSynaptic plasticityTestingTetrodotoxinTherapeuticTraumatic Brain InjuryUp-RegulationVariantVeteransVoltage-Clamp TechnicsWild Type MouseWorkbasechannel blockerscombatdefined contributiondensityexperienceextracellularhippocampal pyramidal neuronin vitro activityin vivoknock-downmetabotropic glutamate receptor 2mossy fiberneural circuitpostsynapticpresynapticpreventprogramsprophylacticpublic health relevancereceptorreceptor bindingreceptor densityreceptor functionresearch studysecond messengersmall hairpin RNAsynaptic functiontherapeutic targettherapy developmentvoltage

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Group I Metabotropic Glutamate Receptors and Epileptogenesis
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