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Pathogenesis of Nerve Injury: Role of Matrix Metalloproteinases

Pathogenesis of Nerve Injury: Role of Matrix Metalloproteinases
神经损伤的发病机制：基质金属蛋白酶的作用
批准号：
7919439
负责人：
VERONICA SHUBAYEV
金额：
$0.0万
依托单位：
VA SAN DIEGO HEALTHCARE SYSTEM
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2014-03-31
来源：
https://reporter.nih.gov/project-details/7919439
关键词：
AdhesivesAlcoholismAlgorithmsApoptosisAwardAxonAxotomyBasal laminaCalciumCaliberCell DeathCell Surface ReceptorsCell SurvivalCell physiologyCell surfaceCellsCessation of lifeCoculture TechniquesCollagen Type IVCrush InjuryDataDemyelinationsDeoxyuridineDepositionDevelopmentDiabetes MellitusDistalEnsureEnvironmentEnzyme-Linked Immunosorbent AssayEpidemiologyErbB4 geneFamilyFamily memberFiberFundingGelatinase AGelatinase BGelatinasesGene DeletionGene FamilyGlial Fibrillary Acidic ProteinGoalsGrowthHealthHealthcare SystemsHourImmuneIn VitroIndividualInfiltrationInflammatoryInhibition of Matrix Metalloproteinases PathwayInjuryInsulin-Like Growth Factor IInterventionKnowledgeLigandsLinkMatrix Metalloproteinase InhibitorMatrix MetalloproteinasesMediatingMembraneMessenger RNAMitogen Activated Protein Kinase 1Mitogen-Activated Protein KinasesMitosisModelingMolecularMusMyelinMyelin Associated GlycoproteinMyelin Basic ProteinsMyelin ProteinsNatural regenerationNerveNerve CrushNerve DegenerationNerve FibersNerve RegenerationNeuraxisNeuregulin 1NeuritesNeurodegenerative DisordersNeurogliaNeuronsOligodendrogliaPainPathogenesisPathway interactionsPatientsPeptide HydrolasesPeripheralPeripheral NervesPeripheral Nervous SystemPeripheral nerve injuryPeritoneal MacrophagesPhagocytosisPhenotypePhosphotransferasesPlayPopulationProcessPropertyProtein BiosynthesisProteolysisRattusReceptor Protein-Tyrosine KinasesRecovery of FunctionRecruitment ActivityRegulationResearchRiskRodentRoleSchwann CellsSensorySeriesSignal TransductionSiteSmall Interfering RNASpeedSpinal GangliaSpinal cord injuryStimulusStrokeStromelysin 1SurvivorsSystemTactileTestingTherapeuticTimeTraumaTubeTumor Necrosis Factor-alphaVeteransWallerian DegenerationWestern BlottingWild Type MouseWorkZincallodyniaaxon regenerationbasecell typechronic painclinically relevantcollagenasedesignextracellulargrowth inhibitory proteinshuman TNF proteinimprovedin vivoinhibitor/antagonistinjuredinsightinterestknockout genemRNA Differential Displaysmacrophagenerve injuryneurite growthneuroinflammationneuronal growthneuronal survivalneuroprotectionnovelpainful neuropathypatient populationpreclinical studyprogramsprotein degradationpublic health relevancereceptorregenerativeremyelinationrepairedsciatic nervesuccesstherapeutic target

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