Pathogenesis of Nerve Injury: Role of Matrix Metalloproteinases

神经损伤的发病机制：基质金属蛋白酶的作用

• 批准号: 7919439
• 负责人: VERONICA SHUBAYEV
• 金额: --
• 依托单位: VA SAN DIEGO HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919439
• 关键词: Adhesives; Alcoholism; Algorithms; Apoptosis; Award; Axon; Axotomy; Basal lamina; Calcium; Caliber; Cell Death; Cell Surface Receptors; Cell Survival; Cell physiology; Cell surface; Cells; Cessation of life; Coculture Techniques; Collagen Type IV; Crush Injury; Data; Demyelinations; Deoxyuridine; Deposition; Development; Diabetes Mellitus; Distal; Ensure; Environment; Enzyme-Linked Immunosorbent Assay; Epidemiology; ErbB4 gene; Family; Family member; Fiber; Funding; Gelatinase A; Gelatinase B; Gelatinases; Gene Deletion; Gene Family; Glial Fibrillary Acidic Protein; Goals; Growth; Health; Healthcare Systems; Hour; Immune; In Vitro; Individual; Infiltration; Inflammatory; Inhibition of Matrix Metalloproteinases Pathway; Injury; Insulin-Like Growth Factor I; Intervention; Knowledge; Ligands; Link; Matrix Metalloproteinase Inhibitor; Matrix Metalloproteinases; Mediating; Membrane; Messenger RNA; Mitogen Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Mitosis; Modeling; Molecular; Mus; Myelin; Myelin Associated Glycoprotein; Myelin Basic Proteins; Myelin Proteins; Natural regeneration; Nerve; Nerve Crush; Nerve Degeneration; Nerve Fibers; Nerve Regeneration; Neuraxis; Neuregulin 1; Neurites; Neurodegenerative Disorders; Neuroglia; Neurons; Oligodendroglia; Pain; Pathogenesis; Pathway interactions; Patients; Peptide Hydrolases; Peripheral; Peripheral Nerves; Peripheral Nervous System; Peripheral nerve injury; Peritoneal Macrophages; Phagocytosis; Phenotype; Phosphotransferases; Play; Population; Process; Property; Protein Biosynthesis; Proteolysis; Rattus; Receptor Protein-Tyrosine Kinases; Recovery of Function; Recruitment Activity; Regulation; Research; Risk; Rodent; Role; Schwann Cells; Sensory; Series; Signal Transduction; Site; Small Interfering RNA; Speed; Spinal Ganglia; Spinal cord injury; Stimulus; Stroke; Stromelysin 1; Survivors; System; Tactile; Testing; Therapeutic; Time; Trauma; Tube; Tumor Necrosis Factor-alpha; Veterans; Wallerian Degeneration; Western Blotting; Wild Type Mouse; Work; Zinc; allodynia; axon regeneration; base; cell type; chronic pain; clinically relevant; collagenase; design; extracellular; growth inhibitory proteins; human TNF protein; improved; in vivo; inhibitor/antagonist; injured; insight; interest; knockout gene; mRNA Differential Displays; macrophage; nerve injury; neurite growth; neuroinflammation; neuronal growth; neuronal survival; neuroprotection; novel; painful neuropathy; patient population; preclinical study; programs; protein degradation; public health relevance; receptor; regenerative; remyelination; repaired; sciatic nerve; success; therapeutic target