Multimodal Imaging of Cognitive Control in Individuals with a Family History of Alcoholism

有酗酒家族史的个体认知控制的多模态成像

• 批准号: 10228610
• 负责人: Joseph Patrick Happer
• 金额: $ 3.55万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10228610
• 关键词: Acute; Alcohol consumption; Alcoholic Intoxication; Alcoholism; Alcohols; Anatomy; Anterior; Attenuated; Behavior; Cognitive; Communication; Conflict (Psychology); Development; Environment; Event; Exhibits; Family; Family history of; Goals; Impaired cognition; Impulsivity; Individual; Informal Social Control; Lateral; Magnetic Resonance Imaging; Magnetoencephalography; Maintenance; Matched Group; Measures; Medial; Mediating; Methods; Multimodal Imaging; Neurobiology; Neurocognitive; Pattern; Phase; Predisposition; Prefrontal Cortex; Recording of previous events; Research; Rest; Risk; Risk Factors; Signal Transduction; Structure; alcohol effect; alcohol sensitivity; alcohol use disorder; base; blood oxygen level dependent; cingulate cortex; cognitive control; cognitive task; drinking; environmental change; executive function; experience; family influence; flexibility; hemodynamics; imaging approach; indexing; insight; multimodality; neural circuit; neuroimaging; neurophysiology; relating to nervous system; response; sobriety; temporal measurement

PROJECT SUMMARY/ABSTRACT A positive family history of alcoholism (FHP) is a well-established risk factor for the development of alcohol use disorders (AUD). This vulnerability is multifaceted as it is associated with several individual risk factors such as impaired cognitive control and a low level of response (LR) to the effects of alcohol. Cognitive control is an essential aspect of executive function that allows individuals to flexibly respond to changing environmental demands by integrating past experiences with current goal-directed behavior. Neuroimaging evidence indicates that effective cognitive control relies on activation of the lateral and medial prefrontal cortices (PFC) and functional connectivity between regions. Though limited, evidence from both neurophysiological and hemodynamic methods indicates alterations in neural activation patterns and functional connectivity in FHP individuals. Impaired cognitive control is heavily implicated in the development of AUD through diminished self- regulation of alcohol consumption. In addition to cognitive control deficits, FHP exhibit a low LR to the subjective effects of alcohol, requiring greater amounts to feels similar effects as individuals without a family history. Importantly, acute alcohol intoxication selectively attenuates activation of the lateral and medial PFC, which may contribute to impulsively drinking more than intended. Few studies, however, have examined how the effects of alcohol on the neural circuitry subserving cognitive control are influenced by FHP. Therefore, the overall aim of this proposal is to characterize the neural indices of cognitive control and their sensitivity to the effects of alcohol, as well as the functional connectivity of the underlying network, in FHP individuals compared to a matched group of individuals with no family history of alcoholism. The proposed project will use a multimodal imaging approach with two main aims: (1) use an anatomically-constrained magnetoencephalography (aMEG) method to examine the effects of alcohol intoxication on theta oscillations and long-range co-oscillations in FHP individuals during a cognitively demanding task such as the Stroop task and (2) characterize the neurofunctional network underlying cognitive control as a function of a family history of alcoholism using MRI-based functional connectivity (fcMRI). The aMEG method combines the temporal precision of MEG and the spatial mapping of structural MRI making it possible to examine the effects of alcohol on theta oscillations and co-oscillations. Event-related theta oscillations are sensitive to cognitive effort while co-oscillations integrate neural communication between cortical regions during cognitive control. As a complementary method, the spatial mapping of fcMRI can be used to examine inherent differences in connectivity between regions within a neurofunctional network. The multimodal approach using both aMEG and fcMRI will provide insight into the neural indices of cognitive control and their sensitivity to alcohol intoxication in individuals with a family history of alcoholism. These findings could help elucidate the neurobiological contributions that increase the risk for FHP individuals to develop AUD.

项目摘要/摘要 酗酒的积极家族史（FHP）是建立酒精使用的危险因素 疾病（AUD）。这种脆弱性是多方面的，因为它与几种单个风险因素相关 认知控制受损和对酒精影响的反应水平低（LR）。认知控制是 执行功能的基本方面，使个人可以灵活地响应不断变化的环境 通过将过去的经验与当前目标指导的行为相结合来需求。神经影像证据表明 这种有效的认知控制依赖于侧面和内侧前额叶皮层（PFC）和 区域之间的功能连通性。尽管有限，但来自神经生理学和 血液动力学方法表明神经激活模式和FHP功能连通性的改变 个人。认知控制障碍受损与自我减少的发展有关AUD的发展 饮酒的调节。除了认知控制缺陷外，FHP对主观表现出低LR 酒精的影响，需要更多的量与没有家族史的个人相似。 重要的是，急性酒精中毒选择性地减弱了侧向和内侧PFC的激活，这可能 有助于冲动的饮酒胜于预期。然而，很少有研究研究了如何 神经回路上的酒精受认知控制受到FHP的影响。因此，总体目的 该建议是表征认知控制的神经指标及其对酒精影响的敏感性， 以及基础网络的功能连接性，与匹配的组相比 没有家族酗酒的个人。拟议的项目将使用多模式成像方法 有两个主要目的：（1）使用解剖结构的磁脑电图（AMEG）方法检查 酒精中毒对FHP个体theta振荡和远程共振荡的影响 认知要求要求的任务，例如Stroop任务，（2）表征依据的神经功能网络 认知控制是使用基于MRI的功能连通性（FCMRI）的酒精中毒家族史的函数。 Ameg方法结合了MEG的时间精度和结构MRI制造的空间映射 可以检查酒精对theta振荡和共振荡的影响。与事件有关的Theta 振荡对认知努力敏感，而共振荡则整合了皮质之间的神经通信 认知控制过程中的区域。作为互补方法，FCMRI的空间映射可用于 检查神经功能网络中区域之间连通性的固有差异。多模式 使用Ameg和FCMRI的方法将洞悉认知控制的神经指数及其 对酒精中毒家族史的个体对酒精中毒的敏感性。这些发现可能会有所帮助 阐明神经生物学贡献，增加了FHP个体发展AUD的风险。