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Molecular Mechanism of Immune Therapy for Bone Marrow Failures

Molecular Mechanism of Immune Therapy for Bone Marrow Failures
骨髓衰竭免疫治疗的分子机制
批准号：
7922121
负责人：
Pearlie K Burnette
金额：
$0.0万
依托单位：
JAMES A. HALEY VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2014-03-31
来源：
https://reporter.nih.gov/project-details/7922121
关键词：
AcuteAddressAdhesionsAdoptive TransferAftercareAgeAgingAnimal ModelAnimalsAntigensAntithymoglobulinAplastic AnemiaApplications GrantsAutoimmune DiseasesAutoimmune ProcessAutoimmunityBindingBloodBone MarrowBone Marrow CellsBone Marrow SuppressionCD8B1 geneCaringCell Adhesion MoleculesCellsCleaved cellClinicalClinical DataClinical ResearchComplexCyclophosphamideCyclosporineCytolysisDataDefectDevelopmentDiagnosisDiagnosticDiseaseDisease ProgressionDisease modelDoseDysmyelopoietic SyndromesEffectivenessEndothelial CellsEquilibriumEtiologyEventFailureFoundationsFundingFutureGenetic TranscriptionGoalsHematopoiesisHome environmentHomingImmuneImmune responseImmune systemImmunosuppressive AgentsImmunotherapyIn VitroIncidenceIndividualInflammatoryIntegrin alpha4beta1IntegrinsL-SelectinLaboratoriesLarge granular lymphocyteLeadLife ExpectancyLigandsLinkLymphocyteLymphocyte Homing ReceptorsLymphocytosisLymphoidManuscriptsMatrix MetalloproteinasesMediatingMembraneMetalloproteasesMethotrexateModelingMolecularMonitorMusMyelogenousMyelopoiesisPancytopeniaPathogenesisPathologyPatientsPeripheralPharmaceutical PreparationsPharmacotherapyPopulationProcessProductionProgress ReportsPublishingQuality of lifeRegulationRheumatoid ArthritisRoleSELL geneSpleenSurfaceSyndromeSystemT-Cell ActivationT-Cell DepletionT-LymphocyteTNF-alpha converting enzymeTestingTheophyllineTherapeuticTherapeutic immunosuppressionTimeTransgenic MiceTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1VasculitisVeteransWorkabstractingalpha secretasebasebonechronic T-cell leukemiacytokinecytopeniadesigneffective therapyimprovedin vivoinhibitor/antagonistlymph nodesmeetingsmigrationmouse modelnovel therapeuticspre-clinicalpreclinical studyprogenitorpublic health relevancereceptorresearch studytraffickingtreatment strategy

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