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p75NTR Ligands for Treament of Traumatic Brain Injury

p75NTR Ligands for Treament of Traumatic Brain Injury
用于治疗创伤性脑损伤的 p75NTR 配体
批准号：
7919403
负责人：
STEPHEN M. MASSA
金额：
$0.0万
依托单位：
VETERANS AFFAIRS MED CTR SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-10-01 至 2014-03-31
来源：
https://reporter.nih.gov/project-details/7919403
关键词：
AcuteAddressAdultAnimalsApoptoticBehaviorBehavioralBrainBrain InjuriesBrain-Derived Neurotrophic FactorCause of DeathCell DeathCell Death InhibitionCell Death ProcessCell Differentiation processCell ProliferationCell SurvivalCellsCessation of lifeChronicChronic PhaseClinicalCorticospinal TractsCraniocerebral TraumaDevelopmentDrug KineticsEarly treatmentEffectivenessExhibitsExplosionFocal Brain InjuriesGeneral PopulationGoalsGrowthHippocampus (Brain)HourIn VitroInjuryKnowledgeLeadLifeLigandsMAGED1 geneMAPK8 geneMediatingMemoryModelingMotorMusMyelinNGFR ProteinNatural regenerationNatureNerve Cell SurvivalNerve DegenerationNerve Growth Factor ReceptorsNeuritesNeurologicNeuronsOligodendrogliaOutcomePI3K/AKTPainPathologicPathway interactionsPenetrationPharmaceutical PreparationsPopulationProcessPropertyProto-Oncogene Proteins c-aktRecoveryRehabilitation therapyResearchRoleSignal PathwaySignal TransductionSpinal CordStem cellsStructureSwimmingSymptomsTestingTimeTissuesToxic effectTrainingTraumaTraumatic Brain InjuryTraumatic CNS injuryVeteransWorkaxon regenerationbasecentral nervous system injurycholinergiccombatcontrolled cortical impactdensitydepressive symptomsdisabilitydrug developmenteffective therapyfallsgliogenesisimprovedinjuredinsightknockout animalmind controlmorris water mazenerve stem cellneurogenesisneuronal cell bodyneuronal survivalneurotrophic factorpolypeptidepressurepublic health relevancereceptorreceptor couplingreceptor functionrepairedresearch studyresponsesmall moleculevehicular accident

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