p75NTR Ligands for Treament of Traumatic Brain Injury

用于治疗创伤性脑损伤的 p75NTR 配体

• 批准号: 7919403
• 负责人: STEPHEN M. MASSA
• 金额: --
• 依托单位: VETERANS AFFAIRS MED CTR SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7919403
• 关键词: Acute; Address; Adult; Animals; Apoptotic; Behavior; Behavioral; Brain; Brain Injuries; Brain-Derived Neurotrophic Factor; Cause of Death; Cell Death; Cell Death Inhibition; Cell Death Process; Cell Differentiation process; Cell Proliferation; Cell Survival; Cells; Cessation of life; Chronic; Chronic Phase; Clinical; Corticospinal Tracts; Craniocerebral Trauma; Development; Drug Kinetics; Early treatment; Effectiveness; Exhibits; Explosion; Focal Brain Injuries; General Population; Goals; Growth; Hippocampus (Brain); Hour; In Vitro; Injury; Knowledge; Lead; Life; Ligands; MAGED1 gene; MAPK8 gene; Mediating; Memory; Modeling; Motor; Mus; Myelin; NGFR Protein; Natural regeneration; Nature; Nerve Cell Survival; Nerve Degeneration; Nerve Growth Factor Receptors; Neurites; Neurologic; Neurons; Oligodendroglia; Outcome; PI3K/AKT; Pain; Pathologic; Pathway interactions; Penetration; Pharmaceutical Preparations; Population; Process; Property; Proto-Oncogene Proteins c-akt; Recovery; Rehabilitation therapy; Research; Role; Signal Pathway; Signal Transduction; Spinal Cord; Stem cells; Structure; Swimming; Symptoms; Testing; Time; Tissues; Toxic effect; Training; Trauma; Traumatic Brain Injury; Traumatic CNS injury; Veterans; Work; axon regeneration; base; central nervous system injury; cholinergic; combat; controlled cortical impact; density; depressive symptoms; disability; drug development; effective therapy; falls; gliogenesis; improved; injured; insight; knockout animal; mind control; morris water maze; nerve stem cell; neurogenesis; neuronal cell body; neuronal survival; neurotrophic factor; polypeptide; pressure; public health relevance; receptor; receptor coupling; receptor function; repaired; research study; response; small molecule; vehicular accident